Murti P R, Bhonsle R B, Gupta P C, Daftary D K, Pindborg J J, Mehta F S
Basic Dental Research Unit, Tata Institute of Fundamental Research, Bombay, India.
J Oral Pathol Med. 1995 Apr;24(4):145-52. doi: 10.1111/j.1600-0714.1995.tb01156.x.
Oral submucous fibrosis (OSF) is a high risk precancerous condition, predominantly affecting Indians. Consumption of chilli was hypothesized as an etiologic factor on the basis of ecological observations and a solitary animal experimental study. Subsequent epidemiologic studies that included case-series reports, large cross-sectional surveys, case-control studies, cohort and intervention studies have identified areca nut as the major etiologic agent. Tissue-culture studies involving human fibroblasts, areca nut extracts and areca nut alkaloids supported this etiologic hypothesis by showing fibroblastic proliferation and increased collagen formation. Currently, the role of genetic susceptibility and that of autoimmunity are receiving attention. The influence of nutritional factors, if any, remains unclear.
口腔黏膜下纤维化（OSF）是一种高风险的癌前病变，主要影响印度人。基于生态学观察和一项单独的动物实验研究，食用辣椒被假设为一个病因因素。随后包括病例系列报告、大型横断面调查、病例对照研究、队列研究和干预研究在内的流行病学研究已确定槟榔是主要病因。涉及人成纤维细胞、槟榔提取物和槟榔生物碱的组织培养研究通过显示成纤维细胞增殖和胶原形成增加支持了这一病因假说。目前，遗传易感性和自身免疫的作用正受到关注。营养因素（如果有的话）的影响仍不清楚。
