Shi Yanyan, Song Yahan, Guo Zhijun, Yu Wei, Zheng Huiling, Ding Shigang, Zhan Siyan
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China.
Library of Peking University Third Hospital, Beijing 100191, China.
Intell Med. 2023 Feb;3(1):1-9. doi: 10.1016/j.imed.2022.06.004. Epub 2022 Jul 26.
The coronavirus disease 2019 (COVID-19) pandemic is ravaging the world. Many therapies have been explored to treat COVID-19. This report aimed to assess the global research trends for the development of COVID-19 therapies.
We searched the relevant articles on COVID-19 therapies published from January 1, 2020, to May 25, 2022, in the Web of Science Core Collection Database (WOSCC). VOSviewer 1.6.18 software was used to assess data on the countries, institutions, authors, collaborations, keywords, and journals that were most implicated in COVID-19 pharmacological research. The latest research and changing trends in COVID-19-relevant pharmacological research were analyzed.
After manually eliminating articles that do not meet the requirements, a total of 5,289 studies authored by 32,932 researchers were eventually included in the analyses, which comprised 95 randomized controlled trials. 3,044 (57.6%) studies were published in 2021. The USA conducted the greatest number of studies, followed by China and India. The primary USA collaborators were China and England. The topics covered in the publications included: the general characteristics, the impact on pharmacists' work, the pharmacological research, broad-spectrum antiviral drug therapy and research, and promising targets or preventive measures, such as vaccine. The temporal diagram revealed that the current research hotspots focused on the vaccine, molecular docking, Mpro, and drug delivery keywords.
Comprehensive bibliometric analysis could aid the rapid identification of the principal research topics, potential collaborators, and the direction of future research. Pharmacological research is critical for the development of therapeutic and preventive COVID-19-associated measures. This study may therefore provide valuable information for eradicating COVID-19.
2019冠状病毒病（COVID-19）大流行正在肆虐全球。人们已经探索了多种治疗COVID-19的方法。本报告旨在评估COVID-19治疗方法开发的全球研究趋势。
我们在科学网核心合集数据库（WOSCC）中检索了2020年1月1日至2022年5月25日发表的关于COVID-19治疗方法的相关文章。使用VOSviewer 1.6.18软件评估与COVID-19药理学研究最相关的国家、机构、作者、合作、关键词和期刊的数据。分析了与COVID-19相关药理学研究的最新研究和变化趋势。
在人工剔除不符合要求的文章后，最终纳入分析的共有32932名研究人员撰写的5289项研究，其中包括95项随机对照试验。2021年发表了3044项（57.6%）研究。美国开展的研究数量最多，其次是中国和印度。美国的主要合作对象是中国和英国。出版物涵盖的主题包括：一般特征、对药剂师工作的影响、药理学研究、广谱抗病毒药物治疗与研究，以及有前景的靶点或预防措施，如疫苗。时间图显示，当前的研究热点集中在疫苗、分子对接、Mpro和药物递送等关键词上。
全面的文献计量分析有助于快速识别主要研究主题、潜在合作者和未来研究方向。药理学研究对于开发与COVID-19相关的治疗和预防措施至关重要。因此，本研究可能为根除COVID-19提供有价值的信息。
