Department of Otolaryngology, Lishui People's Hospital, Lishui, 323000 Zhejiang Province, China.
Comput Math Methods Med. 2022 Jul 22;2022:3097436. doi: 10.1155/2022/3097436. eCollection 2022.
The etiology of sudden deafness is still unclear. In recent years, people's life rhythm is getting faster and faster. Fatigue, environment, diet, psychology, and other factors have increased the morbidity rate of sudden deafness and improved the quality of life of patients. And work efficiency is greatly affected.
A study to investigate the clinical efficacy of postauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness with type 2 diabetes.
Sixty patients with sudden deafness who were treated in our hospital from January 2018 to October 2020 were selected as the subjects of this prospective study and divided into 30 cases each in the comparison group and the observation group according to the random number remainder grouping method. The comparison group was treated conventionally, and the observation group was treated with postauricular injection of methylprednisolone sodium succinate on the basis of the comparison group. Patients in the two groups were observed and compared on the 3rd, 6th, and 9th days after treatment with pure-tone hearing threshold checks and regular monitoring of blood glucose, blood rheology, and other indexes.
On the 7th, 14th, and 30th days after treatment, the pure-tone audiometric thresholds of the two groups were gradually decreased, and the changes in the pure-tone audiometric thresholds in the observation group were greater than those in the control group. After lunch on the 6th day and after lunch on the 9th day, it was lower than that in the control group, and the difference was statistically significant ( < 0.05). 30 days after treatment, the blood viscosity, fibrin, and platelet aggregation rate of the observation group were significantly lower than those of the control group. After treatment, the clinical efficacy rate of the observation group was 96%, which was significantly higher than that of the control group, 80%, and the above differences were statistically significant ( < 0.05).
Treatment with postauricular injection of methylprednisolone sodium succinate has shown better therapeutic recovery in patients with sudden deafness, improved pure-tone hearing threshold, reduced risk of blood glucose elevation, and improved clinical outcomes for patients with sudden deafness, providing some reference for the treatment of patients with sudden deafness.
突发性耳聋的病因仍不清楚。近年来，人们的生活节奏越来越快。疲劳、环境、饮食、心理等因素增加了突发性耳聋的发病率，降低了患者的生活质量，极大地影响了工作效率。
研究分析耳后注射甲泼尼龙琥珀酸钠治疗 2 型糖尿病突发性耳聋的临床疗效。
选取我院 2018 年 1 月至 2020 年 10 月收治的 60 例突发性耳聋患者作为前瞻性研究对象，采用随机数余数分组法分为对照组和观察组各 30 例。对照组采用常规治疗，观察组在对照组基础上采用耳后注射甲泼尼龙琥珀酸钠治疗。两组患者分别于治疗后第 3、6、9 天进行纯音听阈检查，并定期监测血糖、血液流变学等指标。
治疗后第 7、14、30 天，两组纯音听阈逐渐降低，观察组纯音听阈变化大于对照组；第 6 天午餐后、第 9 天午餐后观察组均低于对照组，差异有统计学意义（<0.05）。治疗后 30 天，观察组血液黏度、纤维蛋白原、血小板聚集率明显低于对照组；观察组治疗总有效率为 96%，明显高于对照组的 80%，差异有统计学意义（<0.05）。
耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋患者，可更好地恢复患者纯音听阈，降低血糖升高风险，提高患者的临床疗效，为突发性耳聋患者的治疗提供一定参考。
