是滋养还是坚守？基因组分析为分子机器在芽孢形成中的作用提供线索。
To Feed or to Stick? Genomic Analysis Offers Clues for the Role of a Molecular Machine in Endospore Formers.
机构信息
CNRS-UMR8261, Institut de Biologie Physico-Chimique, Université Paris-Diderot, Paris, France.
出版信息
J Bacteriol. 2022 Sep 20;204(9):e0018722. doi: 10.1128/jb.00187-22. Epub 2022 Aug 1.
Abstract
Sporulation in starts with the formation of two adjacent cells and proceeds with the engulfment of the smaller one, the forespore, by the larger one, the mother cell. This critical step involves a core set of conserved genes, some transcribed in the forespore, such as , and others transcribed in the mother cell, such as the eight-gene operon. A model has been proposed in which the SpoIIIA and the SpoIIQ proteins form a channel connecting the mother cell and the forespore, playing the role of a secretion apparatus allowing the mother cell to nurture the fully engulfed forespore. Exploration of the genomes of and has provided informations that are not fully congruent with data from or . The differences observed are correlated with specific physiological features, and alternate, not mutually exclusive views of the function of the SpoIIIA-SpoIIQ complex are presented.
摘要
在芽孢形成过程中，起始于两个相邻细胞的形成，并通过较大的母细胞吞噬较小的前孢子来进行。这一关键步骤涉及一组核心保守基因，其中一些在前孢子中转录，如 ，而另一些则在母细胞中转录，如八基因 操纵子。已经提出了一种模型，其中 SpoIIIA 和 SpoIIQ 蛋白形成一个连接母细胞和前孢子的通道，充当分泌装置，允许母细胞滋养完全被吞噬的前孢子。对 和 的基因组进行探索提供了与 或 数据不完全一致的信息。观察到的差异与特定的生理特征相关联，并提出了 SpoIIIA-SpoIIQ 复合物功能的替代而非相互排斥的观点。
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