Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Epidemiol Health. 2022;44:e2022062. doi: 10.4178/epih.e2022062. Epub 2022 Jul 29.
Studies have suggested that the dietary intake of antioxidant vitamins, such as vitamin C and vitamin E, has a potential role in inhibiting gastric carcinogenesis. The present study investigated the effect of antioxidant vitamins on the incidence of gastric intestinal metaplasia (GIM).
This study included 67,657 Koreans free of GIM who periodically underwent health check-ups. Dietary intake was assessed by a semiquantitative food frequency questionnaire based on the Korean National Health and Nutrition Examination Survey. Participants were categorized into 4 groups by quartiles of dietary vitamin C and vitamin E intake. The Cox proportional hazard assumption was used to determine the multivariable hazard ratio (HR) and 95% confidence interval (95% CI) for GIM.
The third and fourth quartiles of vitamin C intake had a lower risk of GIM than the first quartile (multivariable-adjusted HR, 0.95; 95% CI, 0.88 to 1.03 in the second quartile, HR, 0.88; 95% CI, 0.81 to 0.97 in the third quartile, and HR, 0.85; 95% CI, 0.76 to 0.95 in the fourth quartile). Vitamin E intake greater than the second quartile level was significantly associated with a lower risk of GIM than the first quartile (multivariable-adjusted HR, 0.90; 95% CI, 0.82 to 0.97 in the second quartile, HR, 0.90; 95% CI, 0.82 to 0.99 in the third quartile, and HR, 0.83; 95% CI, 0.74 to 0.94 in the fourth quartile). This association was observed only in the subgroup analysis for men.
Higher dietary intake of vitamin C and vitamin E was associated with a lower risk of GIM.
研究表明，抗氧化维生素（如维生素 C 和维生素 E）的饮食摄入可能在抑制胃癌发生方面发挥作用。本研究调查了抗氧化维生素对胃肠化生（GIM）发生率的影响。
本研究纳入了 67657 名无 GIM 的韩国人，他们定期接受健康检查。通过基于韩国国家健康和营养检查调查的半定量食物频率问卷评估饮食摄入。参与者根据维生素 C 和维生素 E 饮食摄入量的四分位值分为 4 组。Cox 比例风险假设用于确定 GIM 的多变量危险比（HR）和 95%置信区间（95%CI）。
与第一四分位相比，维生素 C 摄入量的第三和第四四分位的 GIM 风险较低（多变量调整 HR，0.95；95%CI，0.88 至 1.03 在第二四分位，HR，0.88；95%CI，0.81 至 0.97 在第三四分位，HR，0.85；95%CI，0.76 至 0.95 在第四四分位）。大于第二四分位水平的维生素 E 摄入量与 GIM 风险降低显著相关，与第一四分位相比（多变量调整 HR，0.90；95%CI，0.82 至 0.97 在第二四分位，HR，0.90；95%CI，0.82 至 0.99 在第三四分位，HR，0.83；95%CI，0.74 至 0.94 在第四四分位）。这种关联仅在男性亚组分析中观察到。
较高的饮食摄入维生素 C 和维生素 E 与较低的 GIM 风险相关。
