Abd Ziad H, Muter Samir A, Saeed Ruya Abdulhadi M, Ammar Omar
College of Medicine, Department of Surgery, University of Anbar, Ramadi, Iraq.
College of Medicine, Department of Surgery, University of Baghdad, Baghdad, Iraq.
Basic Clin Androl. 2022 Aug 2;32(1):13. doi: 10.1186/s12610-022-00163-x.
The possible effects of COVID-19 vaccines on reproductive health and male fertility in particular have been discussed intensely by the scientific community and the public since their introduction during the pandemic. On news outlets and social media platforms, many claims have been raised regarding the deleterious effects of COVID-19 vaccines on sperm quality without scientific evidence. In response to this emerging conflict, we designed this study to evaluate and assess the effect of the Pfizer-BioNTech mRNA COVID-19 vaccine on male fertility represented by the semen analysis parameters.
Comparing the semen parameters of the participants before and after vaccination, no statistically significant effects on semen volume, pH or normal sperm concentration and morphology were shown. However, there were statistically significant differences on total sperm motility (P = 0.05) and progressive motility (P = 0.02). These differences are clinically insignificant given the fact that both readings before and after vaccination were within the normal ranges, according to the WHO manual guidelines for the examination and processing of human semen.
Our data suggest that the Pfizer-BioNTech mRNA COVID-19 vaccine has no deleterious effects on semen parameters.
自新冠疫情期间新冠疫苗问世以来，科学界和公众就其对生殖健康尤其是男性生育能力的潜在影响展开了激烈讨论。在新闻媒体和社交媒体平台上，许多人在没有科学依据的情况下声称新冠疫苗会对精子质量产生有害影响。针对这一新兴的争议，我们设计了本研究，以评估辉瑞 - 生物科技公司的mRNA新冠疫苗对以精液分析参数为代表的男性生育能力的影响。
比较参与者接种疫苗前后的精液参数，未发现对精液量、pH值或正常精子浓度及形态有统计学上的显著影响。然而，在总精子活力（P = 0.05）和渐进性活力（P = 0.02）方面存在统计学上的显著差异。根据世界卫生组织关于人类精液检查和处理的手册指南，鉴于接种疫苗前后的读数均在正常范围内，这些差异在临床上并无显著意义。
我们的数据表明，辉瑞 - 生物科技公司的mRNA新冠疫苗对精液参数没有有害影响。
