Sura Karna T, Kohman Leslie, Huang Danning, Pasniciuc Silviu V
Department of Radiation Oncology, Upstate University Hospital, Syracuse, USA.
Department of Surgery, Upstate University Hospital, Syracuse, USA.
Cureus. 2022 Jun 28;14(6):e26406. doi: 10.7759/cureus.26406. eCollection 2022 Jun.
Medical marijuana is a symptom treatment option for palliative cancer patients; however, its useful applications remain limited. The goals of this study were to review the characteristics of patients who received medical marijuana under our ambulatory palliative care program and to determine barriers to access and use of medical marijuana in this population.
This study was a retrospective analysis of patients who were enrolled in the medical marijuana registry through the ambulatory palliative care department at Upstate Cancer Center. Data from June 2017 to June 2020 were analyzed. Patients were included if they had a diagnosis of cancer, were certified by a qualified practitioner in the New York Medical Marijuana Program, and received care at Upstate Medical University. Patients were excluded if no marijuana certificate was found or if they transferred care.
The study population was 184 patients. Ninety-three patients (51.5%) received at least one prescription from a New York licensed marijuana dispensary while 72 (39.13%) were certified but never obtained any medical marijuana. For patients who took at least one dose of medical marijuana, 48.14% experienced an improvement in pain, 44.95% used fewer opioids, and 85.11% had an improvement in at least one symptom. Adverse effects were low at 3.72%.
Medical marijuana has an important role in the palliation of symptoms in advanced cancers with few adverse effects. There are still many barriers to effective use. More prospective research is needed to optimize delivery and dosing.
医用大麻是姑息治疗癌症患者的一种症状治疗选择;然而,其有效应用仍然有限。本研究的目的是回顾在我们的门诊姑息治疗项目下接受医用大麻治疗的患者特征,并确定该人群在获取和使用医用大麻方面的障碍。
本研究是对通过上州癌症中心门诊姑息治疗部门登记在医用大麻注册系统中的患者进行的回顾性分析。分析了2017年6月至2020年6月的数据。纳入标准为诊断为癌症、经纽约医用大麻项目的合格从业者认证且在上州医科大学接受治疗的患者。若未找到大麻证书或患者转诊,则将其排除。
研究人群为184名患者。93名患者(51.5%)从纽约持牌大麻药房获得了至少一张处方,而72名患者(39.13%)获得了认证但从未获取过任何医用大麻。对于服用了至少一剂医用大麻的患者,48.14%的患者疼痛得到改善,44.95%的患者减少了阿片类药物的使用,85.11%的患者至少有一种症状得到改善。不良反应发生率较低,为3.72%。
医用大麻在晚期癌症症状缓解中具有重要作用,不良反应较少。有效使用仍存在许多障碍。需要更多前瞻性研究来优化给药方式和剂量。