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Microdystrophin Therapy Rescues Impaired Na Currents in Cardiac Purkinje Fibers From Dystrophin-Deficient Mdx Mice.

作者信息

Ebner Janine, Pan Xiufang, Yue Yongping, Sideromenos Spyridon, Marksteiner Jessica, Koenig Xaver, Hilber Karlheinz, Duan Dongsheng

机构信息

Department of Neurophysiology & Neuropharmacology, Center for Physiology & Pharmacology, Medical University of Vienna, Vienna, Austria (J.E., S.S., J.M., X.K., K.H.).

Department of Molecular Microbiology & Immunology (X.P., Y.Y., D.D.).

出版信息

Circ Arrhythm Electrophysiol. 2022 Aug;15(8):e011161. doi: 10.1161/CIRCEP.122.011161. Epub 2022 Aug 2.

Abstract
摘要

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本文引用的文献

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Duchenne muscular dystrophy.
Nat Rev Dis Primers. 2021 Feb 18;7(1):13. doi: 10.1038/s41572-021-00248-3.
2
Reduced Na current in Purkinje fibers explains cardiac conduction defects and arrhythmias in Duchenne muscular dystrophy.
Am J Physiol Heart Circ Physiol. 2020 Jun 1;318(6):H1436-H1440. doi: 10.1152/ajpheart.00224.2020. Epub 2020 May 8.
3
Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy.
Mol Ther. 2018 Oct 3;26(10):2337-2356. doi: 10.1016/j.ymthe.2018.07.011. Epub 2018 Jul 17.

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