Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Faculty of Pharmacy, The university of Lahore, Lahore, Pakistan.
Biomater Adv. 2022 Sep;140:213049. doi: 10.1016/j.bioadv.2022.213049. Epub 2022 Jul 27.
The overwhelming potential of porous coordination polymers (PCP), also known as Metal-Organic Frameworks (MOFs), especially their nanostructures for various biomedical applications, have made these materials worth investigating for more applications and uses. MOFs unique structure has enabled them for most applications, particularly in biomedical and healthcare. A number of very informative review papers are available on the biomedical applications of MOFs for the reader's convenience. However, many of those reviews focus mainly on drug delivery applications, and no significant work has been reported on other MOFs for biomedical applications. This review aims to present a compact and highly informative global assessment of the recent developments in biomedical applications (excluding drug-delivery) of MOFs along with critical analysis. Researchers have recently adopted both synthetic and post-synthetic routes for the fabrication and modification of MOFs that have been discussed and analyzed. A critical review of the latest reports on the significant and exotic area of bio-sensing capabilities and applications of MOFs has been given in this study. In addition, other essential applications of MOFs, including photothermal therapy, photodynamic therapy, and antimicrobial activities, are also included. These recently grown emergent techniques and cancer treatment options have gained attention and require further investigations to achieve fruitful outcomes. MOF's role in these applications has been thoroughly discussed, along with future challenges and valuable suggestions for the research community that will help meet future demands.
多孔配位聚合物（PCP），也称为金属-有机骨架（MOF），具有巨大的潜在应用价值，特别是它们的纳米结构在各种生物医学应用中，这些材料值得进一步研究和应用。MOF 的独特结构使它们适用于大多数应用，特别是在生物医学和医疗保健领域。为了方便读者，已经有许多关于 MOF 在生物医学应用的非常有启发性的综述文章。然而，许多综述主要集中在药物传递应用上，而对于其他 MOF 在生物医学应用方面的工作却没有得到显著报道。本综述旨在对 MOF 在生物医学应用（不包括药物传递）方面的最新进展进行紧凑而高度信息丰富的全球评估，并进行批判性分析。研究人员最近采用了合成和后合成途径来制造和修饰 MOF，这些方法已经进行了讨论和分析。在这项研究中，对 MOF 在生物传感能力和应用的最新报告进行了批判性综述。此外，还包括 MOF 的其他重要应用，如光热治疗、光动力治疗和抗菌活性。这些新兴的技术和癌症治疗方法已经引起了关注，需要进一步的研究来取得富有成效的结果。本研究还深入讨论了 MOF 在这些应用中的作用，以及未来的挑战和对研究界的有价值建议，这将有助于满足未来的需求。
