Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh, District 4, Ho Chi Minh City 755414, Vietnam; Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet Street, District 10, Ho Chi Minh City, Vietnam; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam.
Faculty of Science, Nong Lam University, Thu Duc District, Ho Chi Minh City 700000, Vietnam.
Sci Total Environ. 2024 Jan 1;906:167295. doi: 10.1016/j.scitotenv.2023.167295. Epub 2023 Sep 22.
One of the representative coordination polymers, metal-organic frameworks (MOFs) material, is of hotspot interest in the multi field thanks to their unique structural characteristics and properties. As a novel hierarchical structural class, MOFs show diverse topologies, intrinsic behaviors, flexibility, etc. However, bare MOFs have less desirable biofunction, high humid sensitivity and instability in water, restraining their efficiencies in biomedical and environmental applications. Thus, a structural modification is required to address such drawbacks. Herein, we pinpoint new strategies in the synthesis and functionalization of MOFs to meet demanding requirements in in vitro tests, i.e., antibacterial face masks against corona virus infection and in wound healing and nanocarriers for drug delivery in anticancer. Regarding the treatment of wastewater containing emerging pollutants such as POPs, PFAS, and PPCPs, functionalized MOFs showed excellent performance with high efficiency and selectivity. Challenges in toxicity, vast database of clinical trials for biomedical tests and production cost can be still presented. MOFs-based composites can be, however, a bright candidate for reasonable replacement of traditional nanomaterials in biomedical and wastewater treatment applications.
其中一种具有代表性的配位聚合物，金属-有机骨架（MOFs）材料，由于其独特的结构特征和性能，在多领域引起了极大的关注。作为一种新型的分级结构类别，MOFs 表现出多样的拓扑结构、内在行为、灵活性等。然而，裸 MOFs 的生物功能较差，对水的湿度敏感且不稳定，限制了它们在生物医学和环境应用中的效率。因此，需要进行结构修饰来解决这些缺点。本文中，我们重点介绍了 MOFs 的合成和功能化的新策略，以满足体外试验的苛刻要求，例如针对冠状病毒感染的抗菌面膜、伤口愈合和抗癌药物输送的纳米载体。在处理含有持久性有机污染物（POPs）、全氟辛酸（PFAS）和个人护理产品（PPCPs）等新兴污染物的废水方面，功能化 MOFs 表现出优异的性能，具有高效率和选择性。然而，毒性方面的挑战、生物医学测试的临床试验庞大数据库和生产成本仍然存在。基于 MOFs 的复合材料可能是合理替代生物医学和废水处理应用中传统纳米材料的有希望的候选材料。
