School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Center for Pharmaceutics Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, China.
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Biochem Pharmacol. 2022 Sep;203:115195. doi: 10.1016/j.bcp.2022.115195. Epub 2022 Jul 30.
Given the high rate of nonresponse or resistance to current inflammatory bowel disease (IBD) treatments, novel drug targets and biomarkers that aid in therapeutic prediction are eagerly demanded. Transient receptor potential (TRP) channels are distributed in the gastrointestinal tract (GI) and visceral sensory nervous systems with multiple functions. An upsurge is observed in the amount of research that implicates TRP channels in several physiological and pathological process of IBD, suggesting the therapeutic potential of the TRP channels as drug targets for combating IBD. In this review, we focus on the expression levels and functions of TRP channels in GI and discuss their potential roles in IBD, including neuropeptide modulation, immune response, and the effect of TRP channels on the IBD-related pathological activities, and some experimental methods for TRP, providing theoretical support for future research.
鉴于当前炎症性肠病（IBD）治疗方法的高应答率或耐药率，人们迫切需要新的药物靶点和生物标志物来辅助治疗预测。瞬时受体电位（TRP）通道分布在胃肠道（GI）和内脏感觉神经系统中，具有多种功能。越来越多的研究表明 TRP 通道参与了 IBD 的多种生理和病理过程，这表明 TRP 通道作为治疗 IBD 的药物靶点具有潜在的治疗作用。在这篇综述中，我们重点讨论了 TRP 通道在 GI 中的表达水平和功能，并讨论了它们在 IBD 中的潜在作用，包括神经肽调节、免疫反应以及 TRP 通道对 IBD 相关病理活动的影响，还介绍了一些 TRP 的实验方法，为未来的研究提供了理论支持。
