Maurus Isabel, Röll Lukas, Keeser Daniel, Karali Temmuz, Papazov Boris, Hasan Alkomiet, Schmitt Andrea, Papazova Irina, Lembeck Moritz, Hirjak Dusan, Thieme Cristina E, Sykorova Eliska, Münz Susanne, Seitz Valentina, Greska David, Campana Mattia, Wagner Elias, Löhrs Lisa, Pömsl Johannes, Roeh Astrid, Malchow Berend, Keller-Varady Katriona, Ertl-Wagner Birgit, Stöcklein Sophia, Meyer-Lindenberg Andreas, Falkai Peter
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
NeuroImaging Core Unit Munich (NICUM), University Hospital LMU, Munich, Germany.
Schizophrenia (Heidelb). 2022 Aug 2;8(1):63. doi: 10.1038/s41537-022-00269-1.
Negative symptoms and cognitive deficits are common in individuals with schizophrenia, greatly affect their outcome, and have been associated with alterations in cerebral gray and white matter volume (GMV, WMV). In the last decade, aerobic endurance training has emerged as a promising intervention to alleviate these symptoms and improved aerobic fitness has been suggested as a key moderator variable. In the present study, we investigated, whether aerobic fitness is associated with fewer cognitive deficits and negative symptoms and with GMVs and WMVs in individuals with schizophrenia in a cross-sectional design. In the largest study to date on the implications of fitness in individuals with schizophrenia, 111 participants at two centers underwent assessments of negative symptoms, cognitive functioning, and aerobic fitness and 69 underwent additional structural magnetic resonance imaging. Multilevel Bayesian partial correlations were computed to quantify relationships between the variables of interest. The main finding was a positive association of aerobic fitness with right hippocampal GMV and WMVs in parahippocampal and several cerebellar regions. We found limited evidence for an association of aerobic fitness with cognitive functioning and negative symptoms. In summary, our results strengthen the notion that aerobic fitness and hippocampal plasticity are interrelated which holds implications for the design of exercise interventions in individuals with schizophrenia.
阴性症状和认知缺陷在精神分裂症患者中很常见，极大地影响他们的预后，并且与脑灰质和白质体积（GMV，WMV）的改变有关。在过去十年中，有氧耐力训练已成为一种有前景的干预措施，可缓解这些症状，且有氧适能的改善被认为是一个关键的调节变量。在本研究中，我们采用横断面设计调查了精神分裂症患者的有氧适能是否与较少的认知缺陷和阴性症状以及GMV和WMV相关。在迄今为止关于适能对精神分裂症患者影响的最大规模研究中，两个中心的111名参与者接受了阴性症状、认知功能和有氧适能的评估，69名参与者还接受了额外的结构磁共振成像检查。计算多级贝叶斯偏相关以量化感兴趣变量之间的关系。主要发现是有氧适能与右侧海马GMV以及海马旁和几个小脑区域的WMV呈正相关。我们发现有氧适能与认知功能和阴性症状之间关联的证据有限。总之，我们的结果强化了有氧适能与海马可塑性相互关联的观点，这对精神分裂症患者运动干预的设计具有启示意义。
