Leroux Elise, Masson Laura, Tréhout Maxime, Dollfus Sonia
"Physiopathology and Imaging of Neurological Disorders" PhIND, UMR-S U1237, INSERM, GIP Cyceron, 14000 Caen, France.
CHU de Caen Normandie, Centre Esquirol, Service de Psychiatrie Adulte, 14000 Caen, France.
Brain Sci. 2024 Jul 15;14(7):710. doi: 10.3390/brainsci14070710.
Schizophrenia is associated with changes in white matter (WM) integrity and with reduced life expectancy, in part because of the cardiometabolic side effects of antipsychotics. Physical activity (PA) has emerged as a candidate lifestyle intervention that is safe and effective. The study aimed to assess how an adapted PA program delivered remotely by web (e-APA) improved WM integrity in patients with schizophrenia (SZPs) and healthy controls (HCs) and to evaluate associations among WM integrity, cardiorespiratory fitness, and symptom severity. This longitudinal study was conducted over 16 weeks with 31 participants (18 SZPs and 13 HCs). Diffusion tensor imaging and tract-based spatial statistics were employed to assess WM integrity. Cardiorespiratory fitness was measured by maximal oxygen uptake (VOmax), and assessments for clinical symptoms included the Positive and Negative Syndrome Scale, Self-evaluation of Negative Symptoms and the Brief Negative Syndrome Scale (BNSS). Only the SZPs had significantly increased WM integrity after the e-APA program, with increased fractional anisotropy and decreased radial diffusivity in fasciculi involved in motor functions and language process. Furthermore, decreased negative symptoms assessed with BNSS were associated with greater WM integrity following the program. These findings suggest that e-APA may improve WM integrity abnormalities and support e-APA as a promising therapeutic strategy.
精神分裂症与白质（WM）完整性改变及预期寿命缩短有关，部分原因是抗精神病药物的心脏代谢副作用。体育活动（PA）已成为一种安全有效的候选生活方式干预措施。该研究旨在评估通过网络远程提供的适应性PA计划（e-APA）如何改善精神分裂症患者（SZP）和健康对照者（HC）的WM完整性，并评估WM完整性、心肺适能和症状严重程度之间的关联。这项纵向研究对31名参与者（18名SZP和13名HC）进行了16周。采用扩散张量成像和基于纤维束的空间统计学方法评估WM完整性。通过最大摄氧量（VOmax）测量心肺适能，临床症状评估包括阳性和阴性症状量表、阴性症状自我评估和简明阴性症状量表（BNSS）。只有SZP在e-APA计划后WM完整性显著增加，参与运动功能和语言处理的纤维束中分数各向异性增加，径向扩散率降低。此外，该计划后用BNSS评估的阴性症状减少与更高的WM完整性相关。这些发现表明，e-APA可能改善WM完整性异常，并支持e-APA作为一种有前景的治疗策略。
