Clinical laboratory, the second people's hospital of Lishui, Lishui city, China.
Clinical laboratory, Ningbo haishu No. 3 Hospital, China.
Scott Med J. 2022 Nov;67(4):135-143. doi: 10.1177/00369330221117557. Epub 2022 Aug 2.
Different prospective cohort studies have focused on the C-reactive protein (, a pentameric protein) biomarker as a predictor of post-stroke depression. In this review and meta-analysis, we will attempt to synthesize the evidence for the association between C-reactive protein and the development of post-stroke depression.
We systematically searched five academic databases for relevant studies according to the PRISMA guidelines. We evaluate the comparative levels of C-reactive protein in patients with stroke and/without depression, and analyzed the hazard ratio to evaluate the overall risk of C-reactive protein levels in patients with stroke.
We selected eligible studies with 2534 patients (mean age: 65.2 ± 5.9 years) from the initial 10 926 studies in the databases. Increased C-reactive protein levels (Hedge's , 0.84) in patients with stroke and depression as compared to patients with stroke without depression. Increased levels of C-reactive protein were associated with the onset of depression (Hazard's ratio, 1.6) in patients with stroke.
Our findings provide an association of C-reactive protein with the development of post-stroke depression, and present higher levels than patients with stroke without depression. Additionally, our findings support the role of C-reactive protein levels as markers for predicting depression in patients with stroke.
不同的前瞻性队列研究集中于 C 反应蛋白（一种五聚体蛋白）生物标志物作为卒中后抑郁的预测因子。在本综述和荟萃分析中，我们将尝试综合 C 反应蛋白与卒中后抑郁发展之间关联的证据。
我们根据 PRISMA 指南系统地在五个学术数据库中搜索了相关研究。我们评估了卒中患者伴或不伴抑郁时 C 反应蛋白的比较水平，并分析了风险比，以评估卒中患者 C 反应蛋白水平的总体风险。
我们从数据库中最初的 10926 项研究中选择了 2534 名患者（平均年龄：65.2±5.9 岁）的合格研究。与卒中但无抑郁的患者相比，卒中伴抑郁患者的 C 反应蛋白水平升高（Hedge's ，0.84）。卒中患者中 C 反应蛋白水平升高与抑郁发作相关（危险比，1.6）。
我们的研究结果表明 C 反应蛋白与卒中后抑郁的发展有关，并且其水平高于卒中但无抑郁的患者。此外，我们的研究结果支持 C 反应蛋白水平作为预测卒中患者抑郁的标志物的作用。
