Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Ningbo No.2 Hospital, 41 Northwest Street, Ningbo, 315000, Zhejiang, China.
Center for Cardiovascular and Cerebrovascular Epidemiology and Translational Medicine, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, 315000, China.
Metab Brain Dis. 2023 Dec;38(8):2521-2546. doi: 10.1007/s11011-023-01262-y. Epub 2023 Jul 13.
Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of mortality and long-term injury. The prediction and early diagnosis of IS are therefore crucial for optimal clinical intervention. Proteomics has provided important techniques for exploring protein markers associated with IS, but there has been no systematic evaluation and review of research that has used these techniques. Here, we review the differential proteins that have been found in cell- and animal- based studies and clinical trials of IS in the past 10 years; determine the key pathological proteins that have been identified in clinical trials; summarize the target proteins affected by interventions aimed at treating IS, with a focus on traditional Chinese medicine treatments. Overall, we clarify findings and problems that have been identified in recent proteomics research on IS and provide suggestions for improvements in this area. We also suggest areas that could be explored for determining the pathogenesis and developing interventions for IS.
缺血性脑卒中（IS）是最常见的脑卒中类型，具有高死亡率和长期损伤的特点。因此，IS 的预测和早期诊断对于最佳临床干预至关重要。蛋白质组学为探索与 IS 相关的蛋白质标志物提供了重要技术，但尚未对使用这些技术的研究进行系统的评估和综述。在这里，我们回顾了过去 10 年中基于细胞和动物的 IS 研究以及临床试验中发现的差异蛋白；确定了临床试验中确定的关键病理蛋白；总结了针对治疗 IS 的干预措施所影响的目标蛋白，重点是中药治疗。总的来说，我们阐明了最近 IS 蛋白质组学研究中发现的结果和问题，并为该领域的改进提出了建议。我们还提出了可以探索确定 IS 发病机制和开发干预措施的领域。
