Admasu Fitalew Tadele, Demissie Biruk, Yitbarek Getachew Yideg, Geto Zeleke, Tesfaw Aragaw, Zewde Edget Abebe, Tilahun Animut, Walle Gashaw, Bekele Tigist Tefera, Habte Mezgebu Legesse, Feyisa Teka Obsa, Amare Tadeg Jemere, Alebachew Wubet, Asnakew Sintayehu, Sisay Ermiyas, Tiruneh Markeshaw, Yemata Getaneh Atikilt, Aytenew Tigabu Munye, Dejenie Tadesse Asmamaw
Department of Biomedical Science, School of Medicine, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, 272, Ethiopia.
Ecancermedicalscience. 2022 May 16;16:1391. doi: 10.3332/ecancer.2022.1391. eCollection 2022.
The exact cause of brain tumours is still unknown, but disruptions of redox balance are thought to play a significant role in all stages of brain tumour development. However, the roles of free radical imbalance at different grades of brain tumour and degree of oxidative stress before and after surgery have not been addressed in prior studies.
A comparative cross-sectional study was conducted to assess the redox imbalance among confirmed brain tumour patients.
An institution-based comparative cross-sectional study was conducted on a total of 100 participants (50 brain tumour patients and 50 controls) at referral hospitals in Addis Ababa, Ethiopia. Descriptive statistics, -test and analysis of variance (ANOVA) () analysis were used and statistical significance was declared at ≤ 0.05. The serum oxidised glutathione and total oxidative stress were significantly higher in the serum of brain tumour patients (0.72 ± 0.03 μM/μg and 9.66 ± 1.76 μmol HO Eq/L, respectively) compared to the control group (0.21 ± 0.07 μM/μg and 6.59 ± 0.81 μmol HO Eq/L, respectively) ( ≤ 0.05). The serum total oxidant status gradually increased as the tumour grade increased, being higher in grade four (11.96 ± 0.72) and lower in grade one (8.43 ± 1.56), and the mean differences were statistically significant ( ≤ 0 05). A statistically significantly higher total antioxidant capacity (116.78 ± 5.03 Trolox Eq/L) was obtained in the post-surgery than pre-surgery level (79.65 ± 17.914 Trolox Eq/L) ( ≤ 0 05).
Higher oxidant and lower antioxidant levels were found in the serum of brain tumour patients than in the control group. The post-surgery oxidant level was lower than the pre-surgery state. The findings of this study could suggest that redox imbalance may have a role in the pathophysiology of brain tumours, but further experimental studies are needed.
脑肿瘤的确切病因仍不清楚，但氧化还原平衡的破坏被认为在脑肿瘤发展的各个阶段都起着重要作用。然而，先前的研究尚未涉及不同分级脑肿瘤中自由基失衡的作用以及手术前后氧化应激程度。
进行一项比较横断面研究，以评估确诊的脑肿瘤患者中的氧化还原失衡情况。
在埃塞俄比亚亚的斯亚贝巴的转诊医院对总共100名参与者（50名脑肿瘤患者和50名对照）进行了一项基于机构的比较横断面研究。使用描述性统计、t检验和方差分析（ANOVA）分析，当P≤0.05时具有统计学意义。与对照组（分别为0.21±0.07μM/μg和6.59±0.81μmol HO Eq/L）相比，脑肿瘤患者血清中的氧化型谷胱甘肽和总氧化应激显著更高（分别为0.72±0.03μM/μg和9.66±1.76μmol HO Eq/L）（P≤0.05）。血清总氧化剂状态随着肿瘤分级的增加而逐渐升高，四级时较高（11.96±0.72），一级时较低（8.43±1.56），平均差异具有统计学意义（P≤0.05）。术后的总抗氧化能力（116.78±5.03 Trolox Eq/L）在统计学上显著高于术前水平（79.65±17.914 Trolox Eq/L）（P≤0.05）。
与对照组相比，脑肿瘤患者血清中氧化剂水平较高，抗氧化剂水平较低。术后氧化剂水平低于术前状态。本研究结果可能表明氧化还原失衡可能在脑肿瘤的病理生理学中起作用，但需要进一步的实验研究。
