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劳力性热射病所致急性肝衰竭与肝移植

Exertional Heat Stroke-Induced Acute Liver Failure and Liver Transplantation.

作者信息

Lin Jessica S, Zaffar Duha, Muhammad Haris, Ting Peng-Sheng, Woreta Tinsay, Kim Amy, Kohli Ruhail, Oshima Kiyoko, Cameron Andrew, Philosophe Benjamin, Ottmann Shane, Wesson Russell, Gurakar Ahmet

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

出版信息

ACG Case Rep J. 2022 Jul 12;9(7):e00820. doi: 10.14309/crj.0000000000000820. eCollection 2022 Jul.

DOI:10.14309/crj.0000000000000820
PMID:35919405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9278910/
Abstract

Exertional heat stroke is a medical emergency characterized by excessive heat production and inadequate heat dissipation usually after heavy exertion in hot and humid climates and can be associated with multiorgan failure. Treatment is largely supportive, but liver transplantation (LT) may be necessary in select patients. Here, we report the case of a 44-year-old runner who was found unconscious after a 5-mile run and developed acute liver failure. He underwent successful LT 1 week later when he developed encephalopathy. This case report illustrates the importance of early LT referral in patients with exertional heat stroke-induced acute liver failure.

摘要

劳力性热射病是一种医疗急症,其特征为产热过多和散热不足,通常发生在炎热潮湿气候下的剧烈运动之后,且可能与多器官功能衰竭相关。治疗主要是支持性的,但在特定患者中可能需要进行肝移植(LT)。在此,我们报告一例44岁跑步者的病例,该患者在进行5英里跑步后被发现昏迷,并发展为急性肝衰竭。1周后当他出现脑病时,接受了成功的肝移植手术。本病例报告说明了对于劳力性热射病诱发急性肝衰竭患者早期转诊进行肝移植的重要性。

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本文引用的文献

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Efficacy and safety of N-acetylcysteine for the treatment of non-acetaminophen-induced acute liver failure: an updated systematic review and meta-analysis.N-乙酰半胱氨酸治疗非对乙酰氨基酚所致急性肝衰竭的疗效与安全性:一项更新的系统评价与Meta分析
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Role of N-acetylcysteine in non-acetaminophen-related acute liver failure: an updated meta-analysis and systematic review.N-乙酰半胱氨酸在非对乙酰氨基酚相关急性肝衰竭中的作用:一项更新的荟萃分析和系统评价
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Front Immunol. 2023 Feb 10;14:1091766. doi: 10.3389/fimmu.2023.1091766. eCollection 2023.
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一种“NAC”的诀窍:治疗热射病引起的急性肝损伤。
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N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis.N-乙酰半胱氨酸(NAC)用于预防热损伤介导的缺血性肝炎中的肝衰竭。
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Liver transplantation in patients with liver failure related to exertional heatstroke.运动性中暑相关肝衰竭患者的肝移植。
J Hepatol. 2019 Mar;70(3):431-439. doi: 10.1016/j.jhep.2018.11.024. Epub 2018 Dec 4.
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Acute liver failure and hepatic encephalopathy in exertional heat stroke.劳力性热射病中的急性肝衰竭和肝性脑病
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Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group.中暑导致急性肝损伤及衰竭:急性肝衰竭研究组的病例系列报道
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