Lagdive Sushma S, Lagdive Sanjay B, Mani Ameet, Anarthe Raju, Pendyala Gowri, Pawar Babita, Marawar Pramod P
Department of Periodontics, Rural Dental College, Loni, Rahata, Ahmednagar, Maharashtra, India.
J Indian Soc Periodontol. 2013 Jan;17(1):63-7. doi: 10.4103/0972-124X.107500.
Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. Mast cells are mobile, bone-marrow-derived, granule-containing immune cells that are found in all connective tissue and mucosal environments and in the peripheral and central nervous systems. Mast cells are able to phagocytose, process and present antigens as effectively as macrophages. The present study was undertaken to quantify the mast cells in health and disease, whether they correlate degree of inflammation and clinical features of periodontium.
Ten cases of localized chronic periodontitis (CP), 10 cases of dental plaque-induced gingivitis (DPIG) and 10 cases of clinically healthy gingival tissues were selected. Samples were obtained from patients undergoing for periodontal surgery in CP and DPIG. In health group third molar impacted and covered with operculum without any inflammation were selected. Sample fixed in 10% buffered formalin and stained with Toludine blue stain and observed under binocular microscope.
In human periodontal disease there is an increase in the number of mast cells that may be participating either in the destructive events or in the defense mechanism of periodontal disease via secretion of cytokines.
在参与牙周疾病免疫和炎症反应的细胞中，肥大细胞已被证明能够产生大量生物活性物质。肥大细胞是可移动的、源自骨髓的、含有颗粒的免疫细胞，存在于所有结缔组织、黏膜环境以及外周和中枢神经系统中。肥大细胞能够像巨噬细胞一样有效地吞噬、处理和呈递抗原。本研究旨在量化健康和患病状态下的肥大细胞，以及它们是否与牙周炎的炎症程度和临床特征相关。
选取10例局限性慢性牙周炎（CP）患者、10例牙菌斑性牙龈炎（DPIG）患者以及10例临床健康的牙龈组织样本。CP组和DPIG组的样本取自接受牙周手术的患者。健康组选取第三磨牙阻生且覆盖龈瓣且无任何炎症的患者。样本用10%缓冲福尔马林固定，甲苯胺蓝染色，在双目显微镜下观察。
在人类牙周疾病中，肥大细胞数量增加，可能通过分泌细胞因子参与牙周疾病的破坏过程或防御机制。
