Al-Qazaz Harith Kh, Al-Obaidy Luma M, Attash Heba M
Department of Clinical Pharmacy, College of Pharmacy, University of Mosul, Ninevah 81011, Iraq.
Pharm Pract (Granada). 2022 Apr-Jun;20(2):2678. doi: 10.18549/PharmPract.2022.2.2678. Epub 2022 Jun 10.
The vaccine was the only way to fight against Coronavirus-19 (COVID-19) from its statement as a pandemic till day. COVID-19 vaccines were approved by the world health organization (WHO) in December 2020. Despite a large number of studies regarding the efficacy and safety of COVID-19 vaccines, to our knowledge, there were limited studies that outlined the gender disparity towards COVID-19 vaccine adverse effects. This study aims to outline the variety of side effects among men and women after getting COVID-19 vaccines (either single or two doses). It is a cross-sectional study accomplished electronically from September to November 2021. The participants involved were 843 Health Care Workers (HCWs) from different cities in Iraq. The majority of respondents were females (664). Around 65% of males experienced adverse effects compared to 77% of females. A high frequency of severe pain was reported among females. Regarding dermatological reactions like swelling, redness and skin rash were also higher reported among female subjects. In addition to that, higher frequencies of moderate and severe systemic adverse effects and mild to moderate nausea was also reported more frequently among females. In terms of cardiopulmonary adverse effects, all the reported adverse effects were found more frequently among females. In conclusion, COVID-19 vaccines produced limited adverse effects and the majority of them were reported among women. This may be associated with hormonal and psychological factors related to them.
从新冠病毒 19（COVID - 19）被宣布为大流行病至今，疫苗一直是对抗它的唯一方法。2020 年 12 月，COVID - 19 疫苗获得了世界卫生组织（WHO）的批准。尽管有大量关于 COVID - 19 疫苗疗效和安全性的研究，但据我们所知，概述 COVID - 19 疫苗不良反应性别差异的研究有限。本研究旨在概述男性和女性接种 COVID - 19 疫苗（单剂或两剂）后的各种副作用。这是一项于 2021 年 9 月至 11 月通过电子方式完成的横断面研究。参与的受试者是来自伊拉克不同城市的 843 名医护人员（HCWs）。大多数受访者为女性（664 名）。约 65%的男性出现了不良反应，而女性为 77%。女性中报告的严重疼痛频率较高。在女性受试者中，关于肿胀、发红和皮疹等皮肤反应的报告也较多。此外，女性中中度和重度全身不良反应以及轻度至中度恶心的发生频率也更高。在心肺不良反应方面，所有报告的不良反应在女性中出现得更为频繁。总之，COVID - 19 疫苗产生的不良反应有限，且大多数报告发生在女性身上。这可能与她们相关的激素和心理因素有关。
