State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
Nucleic Acids Res. 2023 Jan 6;51(D1):D792-D804. doi: 10.1093/nar/gkac646.
ABC portal (http://abc.sklehabc.com) is a database and web portal containing 198 single-cell transcriptomic datasets of development, differentiation and disorder of blood/immune cells. All the datasets were re-annotated with a manually curated and unified single-cell reference, especially for the haematopoietic stem and progenitor cells. ABC portal provides web-based interactive analysis modules, especially a comprehensive cell-cell communication analysis and disease-related gene signature analysis. Importantly, ABC portal allows customized sample selection based on a combination of several metadata for downstream analysis and comparison analysis across datasets. ABC portal also allows users to select multiple cell types for analysis in the modules. Together, ABC portal provides an interactive interface of single-cell data exploration and re-analysis with customized analysis modules for the researchers and clinicians, and will facilitate understanding of haematopoiesis and blood/immune disorders.
ABC 门户（http://abc.sklehabc.com）是一个数据库和网络门户，包含 198 个关于血液/免疫细胞发育、分化和疾病的单细胞转录组数据集。所有数据集都使用手动注释和统一的单细胞参考进行了重新注释，特别是对于造血干细胞和祖细胞。ABC 门户提供基于网络的交互式分析模块，特别是全面的细胞间通讯分析和与疾病相关的基因特征分析。重要的是，ABC 门户允许根据几个元数据的组合进行自定义样本选择，以便进行下游分析和跨数据集的比较分析。ABC 门户还允许用户在模块中选择多个细胞类型进行分析。总之，ABC 门户为研究人员和临床医生提供了一个交互式的单细胞数据探索和重新分析界面，并带有自定义分析模块，将有助于理解造血和血液/免疫疾病。
