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人类造血的单细胞转录图谱揭示了异常急性髓系白血病分化的基于遗传和层级的决定因素。

Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation.

作者信息

Zeng Andy G X, Iacobucci Ilaria, Shah Sayyam, Mitchell Amanda, Wong Gordon, Bansal Suraj, Chen David, Gao Qingsong, Kim Hyerin, Kennedy James A, Arruda Andrea, Minden Mark D, Haferlach Torsten, Mullighan Charles G, Dick John E

机构信息

Princess Margaret Cancer Centre, University Health Network, Toronto, Canada.

Department of Molecular Genetics, University of Toronto, Toronto, Canada.

出版信息

Blood Cancer Discov. 2025 Apr 28:OF1-OF18. doi: 10.1158/2643-3230.BCD-24-0342.

DOI:10.1158/2643-3230.BCD-24-0342
PMID:40294241
Abstract

We present a single-cell reference atlas of human hematopoiesis and a computational tool for rapid mapping and classification of healthy and leukemic cells. Applied to AML, this has enabled single-cell analysis at the scale of hundreds of patient samples, revealing the full breadth of derailment of differentiation in AML. See related commentary by Berger and Penter, p. XX.

摘要

我们展示了一份人类造血的单细胞参考图谱以及一种用于对健康细胞和白血病细胞进行快速映射和分类的计算工具。将其应用于急性髓系白血病（AML），这使得能够对数百份患者样本进行单细胞分析，揭示了AML中分化脱轨的全貌。见伯杰和彭特的相关评论，第XX页。

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