Szmidt M, Grzelewska-Rzymowska I, Kowalski M L, Rozniecki J
Allergy. 1987 Apr;42(3):182-5. doi: 10.1111/j.1398-9995.1987.tb02197.x.
A state of tolerance to aspirin (ASA) was induced in 10 aspirin-sensitive patients by daily administration of incremental doses of ASA. No adverse reactions were reported. The initial dose (from 5 to 60 mg) was gradually increased each day up to 300 mg and then doubled. 50 mg indomethacin given the day after administration of 600 mg ASA did not elicit any symptom of intolerance. The authors discuss a possible mechanism of tolerance to aspirin in ASA-sensitive asthmatics after ASA administration, suggesting that it might be connected either with inhibition of the lipooxygenetic pathway of arachidonic acid metabolism or with blockade of the cyclooxygenase supplementary binding site by salicylic acid, a product of acetylsalicylic acid hydrolysis. This would prevent aspirin from binding with the catalytic cyclooxygenase site.
通过每日递增剂量服用阿司匹林（ASA），在10名对阿司匹林敏感的患者中诱导出了对其的耐受性。未报告有不良反应。初始剂量（5至60毫克）每天逐渐增加至300毫克，然后加倍。在服用600毫克ASA后的第二天给予50毫克吲哚美辛，未引发任何不耐受症状。作者讨论了在ASA敏感的哮喘患者服用ASA后对阿司匹林产生耐受性的可能机制，认为这可能与花生四烯酸代谢的脂氧合途径受到抑制或与乙酰水杨酸水解产物水杨酸对环氧化酶辅助结合位点的阻断有关。这将阻止阿司匹林与催化性环氧化酶位点结合。
