Dor P J, Vervloet D, Baldocchi G, Charpin J
Clin Allergy. 1985 Jan;15(1):37-42. doi: 10.1111/j.1365-2222.1985.tb02252.x.
Acetylsalicylic-acid (ASA) intolerance is well recognized as a possible cause for exacerbating asthma. It has been postulated that if this could be overcome, long-term aspirin administration could improve asthma symptoms and enable reduction of the use of other anti-asthmatic drugs. We succeeded in inducing an ASA tolerance in nine corticosteroid-dependent asthmatics, and this tolerance lasted at least 1 month and at most 1 year. Progressive deterioration in lung function was seen, however, in all patients taking ASA for more than 1 month, unless the corticosteroid intake was increased. These results suggest that ASA long-term treatment is of no help to severe corticosteroid-dependent, ASA-sensitive asthmatics. This conclusion differs from other reports on ASA intolerance in asthma.
乙酰水杨酸（ASA）不耐受是公认的可能导致哮喘加重的原因。据推测，如果能够克服这一问题，长期服用阿司匹林可能会改善哮喘症状，并减少其他抗哮喘药物的使用。我们成功地使9名依赖皮质类固醇的哮喘患者产生了ASA耐受性，这种耐受性至少持续了1个月，最长持续了1年。然而，所有服用ASA超过1个月的患者，除非增加皮质类固醇的摄入量，否则肺功能都会逐渐恶化。这些结果表明，长期使用ASA对严重依赖皮质类固醇、对ASA敏感的哮喘患者并无帮助。这一结论与其他关于哮喘患者ASA不耐受的报告不同。
