Kowalski M L, Grzelewska-Rzymowska I, Rozniecki J, Szmidt M
Allergy. 1984 Apr;39(3):171-8. doi: 10.1111/j.1398-9995.1984.tb02621.x.
Twenty-nine patients with asthma and aspirin-sensitivity were studied in an attempt to induce tolerance to aspirin (ASA). Starting with the smallest ASA doses eliciting bronchial obstruction (threshold doses) we doubled the doses on subsequent days and finally achieved good tolerance of 600 mg ASA per day in 27 patients. It was more difficult to achieve tolerance in patients with low ASA-thresholds than in patients with high ones. Daily ASA administration led to prolongation of the refractory state but when the intervals between consecutive doses were increased, aspirin hypersensitivity recurred. The pause sufficient for a recurrence of sensitivity to ASA was measured in 16 patients and ranged from 24 h to 9 days. Twelve patients challenged with indomethacin after ASA-desensitisation showed good drug tolerance.
对29例哮喘且对阿司匹林敏感的患者进行了研究，试图诱导其对阿司匹林（ASA）产生耐受性。从引发支气管阻塞的最小ASA剂量（阈剂量）开始，在随后几天将剂量加倍，最终27例患者实现了每日600 mg ASA的良好耐受性。与高ASA阈值的患者相比，低ASA阈值的患者更难实现耐受性。每日服用ASA会导致不应期延长，但当连续剂量之间的间隔增加时，阿司匹林超敏反应会复发。对16例患者测量了足以使对ASA敏感性复发的停药时间，范围为24小时至9天。12例在ASA脱敏后接受吲哚美辛激发试验的患者显示出良好的药物耐受性。
