Molke Jensen F, Jensen N H, Holk I K, Ravnborg M
Anaesthesia. 1987 May;42(5):470-5. doi: 10.1111/j.1365-2044.1987.tb04036.x.
Ventilatory sensitivity to carbon dioxide was measured in six healthy volunteers before, and at various times up to 20 hours after, administration of epidural buprenorphine 0.15 mg with a modified Read rebreathing technique. The carbon dioxide response curves were depressed in a time-dependent, prolonged and biphasic manner. Significant depression was seen in the intercept values at an end tidal carbon dioxide of 7.2 kPa, for mouth occlusion pressure (p less than 0.01), tidal volume (p less than 0.05) and minute ventilation (p less than 0.05). A significant reduction of slope was obtained only for minute ventilation. Linear regression of respiratory rate changes during carbon dioxide stimulation, did not reach statistical significance. In conclusion, these data indicate that epidural buprenorphine, despite a high lipid solubility, causes respiratory depression to the same extent as epidural morphine. Surveillance of patients who receive epidural buprenorphine for postoperative pain relief is necessary.
采用改良的Read重复呼吸技术，在6名健康志愿者给予0.15毫克硬膜外丁丙诺啡之前以及给药后长达20小时的不同时间，测量其对二氧化碳的通气敏感性。二氧化碳反应曲线呈时间依赖性、持续性和双相性降低。在呼气末二氧化碳分压为7.2kPa时，口腔闭合压（p<0.01）、潮气量（p<0.05）和分钟通气量（p<0.05）的截距值出现显著降低。仅分钟通气量的斜率有显著降低。二氧化碳刺激期间呼吸频率变化的线性回归未达到统计学意义。总之，这些数据表明，硬膜外丁丙诺啡尽管脂溶性高，但引起的呼吸抑制程度与硬膜外吗啡相同。对接受硬膜外丁丙诺啡用于术后镇痛的患者进行监测是必要的。
