School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.
Nat Commun. 2022 Aug 3;13(1):4500. doi: 10.1038/s41467-022-32121-6.
Rapid transmission of the SARS-CoV-2 Omicron variant has led to record-breaking case incidence rates around the world. Since May 2020, the REal-time Assessment of Community Transmission-1 (REACT-1) study tracked the spread of SARS-CoV-2 infection in England through RT-PCR of self-administered throat and nose swabs from randomly-selected participants aged 5 years and over. In January 2022, we found an overall weighted prevalence of 4.41% (n = 102,174), three-fold higher than in November to December 2021; we sequenced 2,374 (99.2%) Omicron infections (19 BA.2), and only 19 (0.79%) Delta, with a growth rate advantage for BA.2 compared to BA.1 or BA.1.1. Prevalence was decreasing overall (reproduction number R = 0.95, 95% credible interval [CrI], 0.93, 0.97), but increasing in children aged 5 to 17 years (R = 1.13, 95% CrI, 1.09, 1.18). In England during January 2022, we observed unprecedented levels of SARS-CoV-2 infection, especially among children, driven by almost complete replacement of Delta by Omicron.
奥密克戎变异株的快速传播导致了全球创纪录的病例发病率。自 2020 年 5 月以来，实时社区传播评估-1（REACT-1）研究通过对随机选择的 5 岁及以上参与者自行采集的咽喉和鼻腔拭子进行 RT-PCR，追踪了 SARS-CoV-2 在英国的传播情况。2022 年 1 月，我们发现总体加权患病率为 4.41%（n=102174），是 2021 年 11 月至 12 月的三倍；我们对 2374 例（99.2%）奥密克戎感染（19 例 BA.2）进行了测序，只有 19 例（0.79%）Delta，BA.2 相对于 BA.1 或 BA.1.1 具有生长优势。总体患病率呈下降趋势（繁殖数 R=0.95，95%可信区间[CrI]，0.93，0.97），但 5 至 17 岁儿童的患病率呈上升趋势（R=1.13，95% CrI，1.09，1.18）。2022 年 1 月，在英格兰，我们观察到了前所未有的 SARS-CoV-2 感染水平，尤其是在儿童中，这主要是由奥密克戎几乎完全取代了德尔塔所致。
