Center for Physiology, Pathophysiology and Biophysics, Institute for Physiology and Pathophysiology, Salzburg, Austria.
Gastein Research Institute, Paracelsus Medical University, Strubergasse 22, 5020, Salzburg, Austria.
BMC Musculoskelet Disord. 2022 Aug 3;23(1):743. doi: 10.1186/s12891-022-05691-1.
Patients with ankylosing spondylitis (AS) have significantly lower quality of life (QoL) than the general population. Holistic interventions addressing QoL comprise spa- or balneotherapy including radon. These interventions have shown to be beneficial in reducing pain and improving QoL in AS-patients. We explored the association of spa-therapy including low-dose radon with QoL in AS-patients over an extended time period.
Registry data collected for the "Radon indication registry" in the Austrian Gastein valley comprising data on QoL (EuroQol EQ-5D) directly before the treatment (baseline), directly(t1), 3 (t2); 6(t3) and 9(t4) months after the treatment, age, sex and body mass index (BMI) were analysed. Linear regression models explored the association of measurement time with 1) EQ-5D-5L utilities and 2) EuroQol visual analogue scale (VAS) score. Alterations of 0.05 (utilities) and 5.00 (VAS) were considered clinically relevant.
Two-hundred-ninety-one AS-patients were included in the analyses. Forty-four percent (n = 128) were women, the mean age was 52 (SD 10) and the average BMI was 26 (SD 4). Utilities (t1: 0.09 [0.07;0.11]; t2: 0.08 [0.06; 0.10]; t3: 0.06 [0.05;0.09]; t4: 0.04 [0.02;0.06]) and VAS (t1: 11.68 [9.38; 13.97]; t2: 12.20 [9.78; 14.61]; t3: 9.70 [7.24; 12.17]; t4: 6.11 [3.57; 8.65]) were significantly higher at all timepoints compared to baseline. Improvements were clinically relevant at all timepoints in case of the VAS and until 6 months after treatment for the utilities.
AS-patients who received spa therapy including radon show significantly and clinically relevant improvements in Qol until 6-9 months after treatment.
强直性脊柱炎（AS）患者的生活质量（QoL）明显低于一般人群。整体干预措施包括温泉或海水浴疗法，包括氡。这些干预措施已被证明可有效减轻 AS 患者的疼痛并改善其生活质量。我们探讨了温泉疗法（包括低剂量氡）与 AS 患者在较长时间内的生活质量之间的关联。
在奥地利加施泰因谷的“氡治疗登记处”中收集的登记数据，包含治疗前（基线）、治疗后即刻（t1）、3 个月（t2）、6 个月（t3）和 9 个月（t4）时的 QoL（欧洲五维健康量表 EQ-5D）直接时间点的数据，年龄、性别和体重指数（BMI）进行了分析。线性回归模型探讨了测量时间与 1）EQ-5D-5L 效用和 2）欧洲五维健康量表视觉模拟评分（VAS）之间的关联。效用变化 0.05 和 VAS 变化 5.00 被认为具有临床意义。
共纳入 291 名 AS 患者进行分析。44%（n=128）为女性，平均年龄为 52（SD 10）岁，平均 BMI 为 26（SD 4）。效用（t1：0.09[0.07；0.11]；t2：0.08[0.06；0.10]；t3：0.06[0.05；0.09]；t4：0.04[0.02；0.06]）和 VAS（t1：11.68[9.38；13.97]；t2：12.20[9.78；14.61]；t3：9.70[7.24；12.17]；t4：6.11[3.57；8.65]）在所有时间点均显著高于基线。VAS 在所有时间点均具有临床意义的改善，而在治疗后 6 个月时，效用具有临床意义的改善。
接受温泉加氡治疗的 AS 患者，在治疗后 6-9 个月内，生活质量有显著和具有临床意义的改善。
