Beier R C, Norman J O, Irvin T R, Witzel D A
Am J Vet Res. 1987 Apr;48(4):583-5.
Components of white snakeroot, a plant toxic to livestock and human beings, were activated by Aroclor 1254-induced rat liver microsomes. The toxic products of microsomal activation were evaluated in murine melanoma (B16F1) cell cultures. Toxic products in white snakeroot were inactive in cell culture systems without microsomal activation. This activation system revealed that at least 2 fractions of white snakeroot were metabolically activated to cytotoxic agents. The autocatalytic inactivator of cytochrome P-450, 1-aminobenzotriazole, inhibited activation of white snakeroot constituents by rat liver microsomes.
白蛇根草是一种对牲畜和人类有毒的植物，其成分可被多氯联苯混合物1254诱导的大鼠肝微粒体激活。在鼠黑色素瘤（B16F1）细胞培养中对微粒体激活的有毒产物进行了评估。在没有微粒体激活的细胞培养系统中，白蛇根草中的有毒产物没有活性。该激活系统表明，白蛇根草至少有2个组分被代谢激活为细胞毒性剂。细胞色素P-450的自动催化失活剂1-氨基苯并三唑可抑制大鼠肝微粒体对白蛇根草成分的激活。
