Coppock R W, Swanson S P, Gelberg H B, Koritz G D, Buck W B, Hoffmann W E
Am J Vet Res. 1987 Apr;48(4):691-5.
In swine and cattle given 0, 0.1, or 0.5 and 0, 0.5 mg of diacetoxyscirpenol (DAS)/kg of body weight, IV, respectively; DAS had a large volume of distribution and total body clearance. The shortness of the interval between halothane and DAS exposures significantly (P greater than 0.05) decreased DAS biotransformation. Urinary excretion of DAS as a parent compound was not an important route of elimination. In swine and cattle, DAS was transformed by sequential deacetylation to monoacetoxyscirpenol and scirpentriol.
分别给猪和牛静脉注射0、0.1或0.5毫克/千克体重的二乙酰氧基藨草镰刀菌烯醇（DAS）以及0、0.5毫克/千克体重的DAS；DAS具有较大的分布容积和全身清除率。氟烷暴露与DAS暴露之间的间隔时间较短，显著（P大于0.05）降低了DAS的生物转化。DAS作为母体化合物的尿液排泄不是重要的消除途径。在猪和牛中，DAS通过连续脱乙酰化转化为单乙酰氧基藨草镰刀菌烯醇和藨草三醇。
