Coppock R W, Gelberg H B, Hoffmann W E, Buck W B
Fundam Appl Toxicol. 1985 Dec;5(6 Pt 1):1034-49. doi: 10.1016/0272-0590(85)90140-x.
Diacetoxyscirpenol (DAS, anguidine) was given intravenously to swine at 0.0, 0.5, and 1.0 mg/kg body wt. In mitotically and metabolically active tissues such as gastrointestinal epithelium and lymphoid aggregates the effects of DAS mimicked radiation poisoning. A quadratic dose-response relationship between the cytotoxicity of DAS and damage to enterocytes was found. Enterocytes in different anatomical regions of the bowel had differing susceptibilities to the toxic effects of DAS. In lymphoid tissues, DAS was preferentially cytotoxic to B-lymphocyte-rich tissues as compared to T-lymphocyte-rich tissues. In all pigs dosed with DAS the bone marrow was void of hemopoietic elements. DAS was cytotoxic to cells with specialized ion pumps, namely, renal tubular, gastric parietal, and salivary ducts. Cell damage in the exocrine and endocrine pancreas and adrenal gland accounted for changes in blood glucose. Endothelial necrosis and hemorrhage were observed in the brain. These findings were compared with those reported for other 12,13-epoxytrichothecenes and ionizing radiation and we concluded that a similar mechanism of cytotoxicity could exist.
将双乙酰氧基镰刀菌烯醇（DAS，安圭定）以0.0、0.5和1.0毫克/千克体重的剂量静脉注射给猪。在有丝分裂和代谢活跃的组织，如胃肠道上皮和淋巴集结中，DAS的作用类似于辐射中毒。发现DAS的细胞毒性与肠上皮细胞损伤之间存在二次剂量反应关系。肠道不同解剖区域的肠上皮细胞对DAS的毒性作用敏感性不同。在淋巴组织中，与富含T淋巴细胞的组织相比，DAS对富含B淋巴细胞的组织具有优先细胞毒性。在所有用DAS给药的猪中，骨髓中没有造血成分。DAS对具有特殊离子泵的细胞具有细胞毒性，即肾小管、胃壁细胞和唾液腺导管。外分泌和内分泌胰腺以及肾上腺的细胞损伤导致血糖变化。在大脑中观察到内皮细胞坏死和出血。将这些发现与其他12,13 - 环氧单端孢霉烯族毒素和电离辐射的报道结果进行了比较，我们得出结论，可能存在类似的细胞毒性机制。
