miR-34a在糖尿病和身体虚弱中的功能作用。
Functional role of miR-34a in diabetes and frailty.
作者信息
Mone Pasquale, de Donato Antonio, Varzideh Fahimeh, Kansakar Urna, Jankauskas Stanislovas S, Pansini Antonella, Santulli Gaetano
机构信息
Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, NY, United States.
ASL Avellino, Avellino, Italy.
出版信息
Front Aging. 2022 Jul 18;3:949924. doi: 10.3389/fragi.2022.949924. eCollection 2022.
Emerging evidence has shown that microRNAs (miRNAs) play critical role in the pathogenesis of several disorders. In the present minireview, we focus our attention on the functional role of a specific miRNA, namely miR-34a, in the pathophysiology of frailty and diabetes mellitus. Based on the current literature, we speculate that this miRNA may serve as a potential biomarker of frailty in diabetic older adults. Additionally, its actions on oxidative stress might represent a druggable target to obtain new potentials treatments.
新出现的证据表明，微小RNA（miRNA）在多种疾病的发病机制中起关键作用。在本微型综述中，我们将注意力集中在一种特定的miRNA，即miR-34a，在衰弱和糖尿病病理生理学中的功能作用上。基于当前的文献，我们推测这种miRNA可能作为糖尿病老年人衰弱的潜在生物标志物。此外，其对氧化应激的作用可能代表一个可药物靶向的目标，以获得新的潜在治疗方法。
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