Zheng Hao-Qi, Ma Yu-Cong, Chen Yu-Quan, Xu Yan-Yue, Pang Yan-Lin, Liu Li
Department of Pediatrics, The First Hospital of Jilin University, Changchun, 130021, People's Republic of China.
Institute of Medical Information/Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100020, People's Republic of China.
Infect Drug Resist. 2022 Jul 28;15:4101-4108. doi: 10.2147/IDR.S372940. eCollection 2022.
Severe mycoplasma pneumoniae (MP) pneumonia can cause bronchiolitis obliterans (BO). In order to improve the prognosis of BO, it is necessary to grasp the clinical characteristics and risk factors of BO after severe MP pneumonia and intervene as soon as possible.
This study retrospectively analyzed the clinical data of 110 patients with severe MP pneumonia, and divided them into BO group (22 cases) and non-BO group (88 cases). The clinical characteristics of BO group were analyzed, and the clinical data of two groups were compared to identify the risk factors of BO.
At the time of diagnosis, all BO patients had symptoms of cough and wheezing, and 10 (45.45%) had decreased exercise intolerance. Lung function showed moderate to severe obstructive ventilatory dysfunction, high-resolution computed tomography (HRCT) showed mosaic perfusion patterns. Multivariate binomial regression analysis showed that higher levels of serum lactate dehydrogenase (LDH) and hypoxemia were independent risk factors for BO after severe MP pneumonia.
Higher levels of serum LDH and hypoxemia were independent risk factors for BO after severe MP pneumonia. For patients with risk factors, clinicians should regular follow-up for early diagnosis and intervention of BO.
重症支原体肺炎（MP）可导致闭塞性细支气管炎（BO）。为改善BO的预后，有必要掌握重症MP肺炎后BO的临床特征和危险因素并尽早干预。
本研究回顾性分析了110例重症MP肺炎患者的临床资料，将其分为BO组（22例）和非BO组（88例）。分析BO组的临床特征，并比较两组临床资料以确定BO的危险因素。
确诊时，所有BO患者均有咳嗽、喘息症状，10例（45.45%）运动耐量下降。肺功能呈中度至重度阻塞性通气功能障碍，高分辨率计算机断层扫描（HRCT）呈马赛克灌注模式。多因素二项回归分析显示，血清乳酸脱氢酶（LDH）水平升高和低氧血症是重症MP肺炎后发生BO的独立危险因素。
血清LDH水平升高和低氧血症是重症MP肺炎后发生BO的独立危险因素。对于有危险因素的患者，临床医生应定期随访以便早期诊断和干预BO。
