Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
School of Engineering Science, College of Engineering, University of Tehran, Tehran, Iran.
J Biomater Sci Polym Ed. 2023 Jan;34(1):72-88. doi: 10.1080/09205063.2022.2110483. Epub 2022 Aug 18.
Kiwi extract (KE) including different components such as quercetin, vitamins C and E, and actinides has been known as a debridement agent for burn wounds. In this study, electrospun poly(ɛ-caprolactone)/cellulose acetate blend nanofibers incorporating KE (PCL/CA/KE) were prepared and their performance was evaluated for healing acceleration of burn wounds. The physicochemical characterization of PCL/CA/KE nanofibers showed an average diameter of ∼420 nm, porosity of 70%, water contact angle of 61°, and water uptake of ∼220%. Moreover, the continuous release trend of KE from PCL/CA blend nanofibers happened during 24 h and the release mechanism was governed by the Fickian diffusion. Besides the cytocompatibility of PCL/CA/KE nanofibers, their experiments revealed that the bioactive wound dressing based on the sample has higher wound closure compared to KE after 21 days. Histopathology of wounds dressed by PCL/CA/KE nanofibers indicated epidermal formation along with a fully extended layer. Eventually, the obtained results confirmed that the PCL/CA/KE nanofibrous sample was a promising wound dressing for burn wound healing.
猕猴桃提取物（KE）包含槲皮素、维生素 C 和维生素 E 等多种成分，被认为是一种用于烧伤创面清创的药物。本研究制备了负载 KE 的聚己内酯/醋酸纤维素共混纳米纤维（PCL/CA/KE），并评估了其促进烧伤创面愈合的性能。PCL/CA/KE 纳米纤维的理化特性分析表明，其平均直径约为 420nm，孔隙率为 70%，水接触角为 61°，吸水率约为 220%。此外，KE 从 PCL/CA 共混纳米纤维中的持续释放趋势发生在 24 小时内，释放机制受菲克扩散控制。除了 PCL/CA/KE 纳米纤维的细胞相容性外，实验还表明，与 KE 相比，基于该样品的活性创面敷料在 21 天后具有更高的创面闭合率。经 PCL/CA/KE 纳米纤维包扎的伤口组织病理学表明表皮形成且完全延伸。最终，研究结果证实，PCL/CA/KE 纳米纤维样剂是一种有前途的用于烧伤创面愈合的创面敷料。
