Edwards A, Atma-Ram A, Thin R N
Department of Genitourinary Medicine, St Thomas's Hospital, London.
Genitourin Med. 1988 Aug;64(4):263-5. doi: 10.1136/sti.64.4.263.
The increasing incidence of genital warts has led to more public awareness of this infection and its possible sequelae. Currently available treatment remains unsatisfactory, and there is pressure to develop effective and convenient alternatives. Podophyllotoxin is standardised and stable, whereas podophyllin has a variable composition. In an open comparison of self applied podophyllotoxin 0.5% versus podophyllin 20% applied by a doctor to treat external penile warts, podophyllotoxin was more effective and gave quicker resolution than podophyllin. Side effects were similar for both preparations, and few patients experienced complications severe enough to stop treatment. Podophyllotoxin can therefore be used safely and effectively for home treatment monitored at an outpatient clinic and provides a useful alternative to treatment with podophyllin at overburdened genitourinary medicine clinics.
尖锐湿疣发病率的上升已使公众对这种感染及其可能的后遗症有了更多认识。目前可用的治疗方法仍不尽人意，因此存在开发有效且便捷替代方法的压力。鬼臼毒素标准化且稳定，而鬼臼树脂成分可变。在一项自我应用0.5%鬼臼毒素与医生应用20%鬼臼树脂治疗阴茎外部疣的开放对比中，鬼臼毒素比鬼臼树脂更有效且疣体消退更快。两种制剂的副作用相似，很少有患者出现严重到足以停止治疗的并发症。因此，鬼臼毒素可在门诊监测下安全有效地用于家庭治疗，为不堪重负的泌尿生殖医学诊所提供了一种有用的替代鬼臼树脂治疗的方法。
