Institut NeuroMyoGène INMG-PGNM, Physiopathologie et Génétique du Neurone et du Muscle, UMR5261, Inserm U1315, Université Claude Bernard UCBL-Lyon1, Faculté de Médecine Rockefeller, Lyon, France.
German Center for Neurodegenerative Diseases Bonn (DZNE), Bonn, Germany.
PLoS Pathog. 2022 Aug 4;18(8):e1010670. doi: 10.1371/journal.ppat.1010670. eCollection 2022 Aug.
Neurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain unknown but likely involve a combination of aging, genetic risk factors, and environmental stressors. Accumulating evidence hints at an association of viruses with neurodegenerative disorders and suggests that virus-induced neuroinflammation and perturbation of neuronal protein quality control can be involved in the early steps of disease development. In this review, we focus on emerging evidence for a correlation between NDs and viral infection and discuss how viral manipulations of cellular processes can affect the formation and dissemination of disease-associated protein aggregates.
神经退行性疾病（NDs），如阿尔茨海默病和帕金森病，是致命的神经疾病，可能有特发性、遗传性，甚至传染性病因，如传染性海绵状脑病。导致神经退行性变的病因尚不清楚，但可能涉及衰老、遗传风险因素和环境应激因素的综合作用。越来越多的证据表明病毒与神经退行性疾病之间存在关联，并提示病毒诱导的神经炎症和神经元蛋白质量控制的紊乱可能参与疾病发展的早期阶段。在这篇综述中，我们重点介绍了 NDs 与病毒感染之间相关性的新证据，并讨论了病毒对细胞过程的操纵如何影响疾病相关蛋白聚集体的形成和传播。
