O'Malley Kate Y, Hart Carl L, Casey Sharon, Downey Luke A
Centre for Human Psychopharmacology, Swinburne University, 427-451 Burwood Road, Hawthorn, Victoria 3122, Australia; Department of Psychology, Columbia University, 1190 Amsterdam Avenue, 406 Schermerhorn, MC 5501, New York, NY 10027, USA.
Department of Psychology, Columbia University, 1190 Amsterdam Avenue, 406 Schermerhorn, MC 5501, New York, NY 10027, USA; Division on Substance Use, New York State Psychiatric Institute, and Department of Psychiatry, 1051 Riverside Drive, MC 120, New York, NY 10032, USA.
Neurosci Biobehav Rev. 2022 Oct;141:104805. doi: 10.1016/j.neubiorev.2022.104805. Epub 2022 Aug 1.
The relationship between amphetamine use and aggressive or violent behaviour is unclear. This review examined laboratory data collected in humans, who were administered an acute dose of amphetamine or methamphetamine, in order to investigate the link between amphetamines and aggression. It is registered with PROSPERO (CRD42019127711). Included in the analysis are data from twenty-eight studies. Behavioural and/or subjective measures of aggression were assessed in one thousand and sixty-nine research participants, with limited amphetamine-use histories, following a single amphetamine dose (0-35 mg). The available published evidence indicates that neither amphetamine nor methamphetamine acutely increased aggression as assessed by traditional laboratory measures. Future research should assess supratherapeutic amphetamine doses as well as include a broader range of multiple aggression measures, facilitating simultaneous assessment of the various components that comprise this complex, multifaceted construct.
安非他明的使用与攻击或暴力行为之间的关系尚不清楚。本综述研究了在人类身上收集的实验室数据，这些人被给予急性剂量的安非他明或甲基苯丙胺，以调查安非他明与攻击行为之间的联系。该研究已在国际前瞻性系统评价注册库（PROSPERO）注册（注册号：CRD42019127711）。分析纳入了28项研究的数据。在1069名安非他明使用史有限的研究参与者中，在单次服用安非他明剂量（0 - 35毫克）后，评估了攻击行为的行为和/或主观测量指标。现有的已发表证据表明，按照传统实验室测量方法评估，安非他明和甲基苯丙胺都不会急性增加攻击行为。未来的研究应评估超治疗剂量的安非他明，并纳入更广泛的多种攻击行为测量指标，以便同时评估构成这一复杂多面概念的各个组成部分。
