Chemistry Division, School of Advanced Science (SAS), Vellore Institute of Technology Chennai, Vandalur- Kelambakkam Road, Chennai-600 127, Tamil Nadu, India.
Department of Science, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia.
Curr Med Chem. 2023;30(21):2421-2448. doi: 10.2174/0929867329666220801165849.
The chemistry of organoselenium reagents provides an asset for organic synthesis. The versatility of these reagents as electrophiles and nucleophiles makes them one of the key components of organic synthesis. Various synthetic transformations such as oxyselenenylations, selenocyclization and selenoxide elimination have been successfully achieved using organoselenium reagents under mild reaction conditions. The presence of selenocysteine in a few mammalian enzymes was the key information for selenium chemists to explore the biochemistry of selenium compounds. Glutathione peroxidase (GPx), a mammalian selenoenzyme, is well known for maintaining redox equilibrium by detoxifying reactive oxygen species.
The aim is to critically analyze the recent development and prospects of synthesis and antioxidant properties of organoselenium compounds.
In this review, we summarised research and review papers from the PubMed and Scopus databases. The primary themes were linked to the synthesis of organoselenium compounds and their capacity to maintain cellular redox equilibrium when exposed to oxidative stress.
The study reveals that diselenide compounds synthesised by various methods showed a better antioxidant activity profile compared to selenides. In a few cases, the activity was found better than the standard compound ebselen. Moreover, the synthesis and antioxidant activity of Selenium-based nanoparticles have been also included.
In the past two decades, various biological properties of organoselenium compounds have been extensively studied, including the antioxidant properties. This review article will give insight into the synthesis of different types of recently synthesised organoselenium compounds. The review would be helpful to the researchers working in the field of medicinal chemistry in directing the synthesis of new organoselenium compounds as antioxidants.
有机硒试剂的化学性质为有机合成提供了一种资产。这些试剂作为亲电试剂和亲核试剂的多功能性使它们成为有机合成的关键组成部分之一。在温和的反应条件下，使用有机硒试剂已经成功地实现了各种合成转化，如氧硒代、硒环化和硒氧化物消除。几种哺乳动物酶中存在硒代半胱氨酸，这是硒化学家探索硒化合物生物化学的关键信息。谷胱甘肽过氧化物酶（GPx）是一种哺乳动物硒酶，通过解毒活性氧来维持氧化还原平衡而广为人知。
目的是批判性地分析有机硒化合物的合成和抗氧化性质的最新发展和前景。
在这篇综述中，我们总结了来自 PubMed 和 Scopus 数据库的研究和综述论文。主要主题与有机硒化合物的合成及其在暴露于氧化应激时维持细胞氧化还原平衡的能力有关。
研究表明，通过各种方法合成的二硒化物化合物表现出比硒化物更好的抗氧化活性谱。在某些情况下，其活性被发现优于标准化合物 ebselen。此外，还包括基于硒的纳米粒子的合成和抗氧化活性。
在过去的二十年中，已经广泛研究了有机硒化合物的各种生物学特性，包括抗氧化特性。这篇综述文章将深入了解最近合成的各种类型有机硒化合物的合成。该综述将有助于从事药物化学领域研究的研究人员指导作为抗氧化剂的新型有机硒化合物的合成。
