Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW 2770, Australia.
AFNP Med, 1030 Wien, Austria.
Curr Med Chem. 2023;30(3):356-370. doi: 10.2174/0929867329666220801152347.
Even though the promising therapies against cancer are rapidly improved, the oncology patients population has seen exponential growth, placing cancer in 5th place among the ten deadliest diseases. Efficient drug delivery systems must overcome multiple barriers and maximize drug delivery to the target tumors, simultaneously limiting side effects. Since the first observation of the quantum tunneling phenomenon, many multidisciplinary studies have offered quantum-inspired solutions to optimized tumor mapping and efficient nanodrug design. The property of a wave function to propagate through a potential barrier offer the capability of obtaining 3D surface profiles using imaging of individual atoms on the surface of a material. The application of quantum tunneling on a scanning tunneling microscope offers an exact surface roughness mapping of tumors and pharmaceutical particles. Critical elements to cancer nanotherapeutics apply the fractal theory and calculate the fractal dimension for efficient tumor surface imaging at the atomic level. This review study presents the latest biological approaches to cancer management based on fractal geometry.
尽管针对癌症的有前途的治疗方法正在迅速改进，但肿瘤患者人数呈指数级增长，癌症在十大致命疾病中排名第五。有效的药物输送系统必须克服多种障碍，将药物最大限度地输送到靶肿瘤，同时限制副作用。自从首次观察到量子隧道现象以来，许多多学科研究为优化肿瘤测绘和高效纳米药物设计提供了量子启发的解决方案。波函数传播通过势垒的特性提供了使用材料表面上的单个原子成像来获得 3D 表面轮廓的能力。在扫描隧道显微镜上应用量子隧道提供了肿瘤和药物颗粒的精确表面粗糙度映射。癌症纳米治疗学的关键要素应用分形理论并计算分形维数，以在原子水平上进行有效的肿瘤表面成像。本综述研究介绍了基于分形几何的癌症管理的最新生物学方法。
