Yu Zhongyang, Gao Lei, Chen Kehan, Zhang Wenqiang, Zhang Qihang, Li Quanwang, Hu Kaiwen
Beijing University of Chinese Medicine, 11 North Third Ring East Road, Chaoyang District, Beijing, 100029, China.
Oncology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Fangguyuan Rd, Fengtai District, Beijing, 100078, China.
Nanoscale Res Lett. 2021 May 20;16(1):88. doi: 10.1186/s11671-021-03489-z.
Traditional cancer therapeutics have been criticized due to various adverse effects and insufficient damage to targeted tumors. The breakthrough of nanoparticles provides a novel approach for upgrading traditional treatments and diagnosis. Actually, nanoparticles can not only solve the shortcomings of traditional cancer diagnosis and treatment, but also create brand-new perspectives and cutting-edge devices for tumor diagnosis and treatment. However, most of the research about nanoparticles stays in vivo and in vitro stage, and only few clinical researches about nanoparticles have been reported. In this review, we first summarize the current applications of nanoparticles in cancer diagnosis and treatment. After that, we propose the challenges that hinder the clinical applications of NPs and provide feasible solutions in combination with the updated literature in the last two years. At the end, we will provide our opinions on the future developments of NPs in tumor diagnosis and treatment.
传统癌症治疗方法因各种不良反应以及对靶向肿瘤的损伤不足而受到批评。纳米颗粒的突破为传统治疗和诊断的升级提供了一种新方法。实际上,纳米颗粒不仅可以解决传统癌症诊断和治疗的缺点,还能为肿瘤诊断和治疗创造全新的视角和前沿设备。然而,大多数关于纳米颗粒的研究仍处于体内和体外阶段,仅有少数关于纳米颗粒的临床研究被报道。在本综述中,我们首先总结纳米颗粒在癌症诊断和治疗中的当前应用。之后,我们提出阻碍纳米颗粒临床应用的挑战,并结合近两年的最新文献提供可行的解决方案。最后,我们将对纳米颗粒在肿瘤诊断和治疗中的未来发展发表看法。