Arnason J A, Jónsson T, Brekkan A, Sigurjónsson K, Valdimarsson H
Ann Rheum Dis. 1987 May;46(5):380-4. doi: 10.1136/ard.46.5.380.
Total rheumatoid factor (RF) activity and individual RF isotypes were measured in 62 patients with rheumatic diseases. Retrospective analysis of available x rays showed an association between IgA RF and the occurrence of periarticular bone erosions in hands. In contrast, IgG RF and IgM RF did not show any significant association with erosions. Furthermore, a close correlation was observed between the RF isotype levels in simultaneously drawn serum and synovial fluid samples. The possible significance of IgA RF in the pathogenesis of bone erosions is discussed.
对62例风湿性疾病患者测定了总类风湿因子（RF）活性及各RF亚型。对现有的X光片进行回顾性分析显示，IgA RF与手部关节周围骨质侵蚀的发生有关。相比之下，IgG RF和IgM RF与骨质侵蚀未显示出任何显著关联。此外，在同时采集的血清和滑液样本中，观察到RF亚型水平之间存在密切相关性。本文讨论了IgA RF在骨质侵蚀发病机制中的可能意义。
