Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Beijing Retinal and Choroidal Vascular Disorders Study Group, Beijing, China.
Front Endocrinol (Lausanne). 2022 Jul 19;13:946327. doi: 10.3389/fendo.2022.946327. eCollection 2022.
Lipid dyshomeostasis has been implicated in the pathogenesis of various retinal and choroidal vascular diseases. This study aims to investigate whether apolipoprotein (apo) mediated differential regulation of lipid metabolism contributes to the phenotypes of polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD). This study involved 148 subjects including 53 patients with PCV, 44 patients with nAMD, and 51 age-, sex-matched subjects with normal fundus controls. Routine blood biochemistry profile was evaluated. Apolipoproteins was estimated by Luminex technology. After controlling for age, gender, body mass index, duration of hypertension and type 2 diabetes mellitus, apoB/non-high density lipoprotein cholesterol (HDL-C) (=0.015) was an independent risk factor for nAMD, apoB was an independent risk factor for PCV(=0.011), compared with control. Low-density lipoprotein cholesterol (LDL-C) was significantly higher in patients with PCV when compared with nAMD (=0.037). Furthermore, apoB/non-HDL, LDL-C, triglycerides and were significantly correlated with the pathogenesis of subgroups of PCV and nAMD. We concluded that lipid profiles and apos are differential regulated in PCV, nAMD and their subtypes, indicating different pathogenicity contributed to the different phenotypes of PCV and nAMD. Non-pachy PCV shares pathological similarities with nAMD, which is highly correlated with age-related atherosclerosis.
脂质代谢失衡与各种视网膜和脉络膜血管疾病的发病机制有关。本研究旨在探讨载脂蛋白（apo）介导的脂质代谢差异调节是否导致息肉样脉络膜血管病变（PCV）和新生血管性年龄相关性黄斑变性（nAMD）的表型。本研究共纳入 148 例受试者，包括 53 例 PCV 患者、44 例 nAMD 患者和 51 名年龄、性别匹配的眼底正常对照者。评估了常规血液生化特征。采用 Luminex 技术测定载脂蛋白。校正年龄、性别、体重指数、高血压和 2 型糖尿病病程后，apoB/非高密度脂蛋白胆固醇（HDL-C）（=0.015）是 nAMD 的独立危险因素，apoB 是 PCV（=0.011）的独立危险因素，与对照组相比。与 nAMD 相比，PCV 患者的低密度脂蛋白胆固醇（LDL-C）明显升高（=0.037）。此外，apoB/非-HDL、LDL-C、甘油三酯与 PCV 和 nAMD 亚组的发病机制显著相关。我们得出结论，脂质谱和载脂蛋白在 PCV、nAMD 及其亚型中存在差异调节，表明不同的发病机制导致了 PCV 和 nAMD 不同的表型。非厚性 PCV 与 nAMD 具有相似的病理特征，与年龄相关性动脉粥样硬化高度相关。
