Esmaili Haleh, Tajik Behnam, Tuomainen Tomi-Pekka, Kurl Sudhir, Salonen Jukka T, Virtanen Jyrki K
University of Eastern Finland, Kuopio Campus, Institute of Public Health and Clinical Nutrition, Kuopio, Finland.
University of Helsinki, the Faculty of Medicine, Department of Public Health, Helsinki, Finland.
Br J Nutr. 2022 Aug 5;129(8):1-10. doi: 10.1017/S0007114522002501.
Low intake or tissue concentrations of the -6 PUFA, especially to the major -6 PUFA linoleic acid (LA), and low exercise cardiac power (ECP) are both associated with CVD risk. However, associations of the -6 PUFA with ECP are unknown. The aim of the present study was to explore cross-sectional associations of the serum total -6 PUFA, LA, arachidonic acid (AA), -linolenic acid (GLA) and dihomo--linolenic acid (DGLA) concentrations with ECP and its components. In total, 1685 men aged 42-60 years from the Kuopio Ischaemic Heart Disease Risk Factor Study and free of CVD were included. ANCOVA was used to examine the mean values of ECP (maximal oxygen uptake (VO)/maximal systolic blood pressure (SBP)) and its components in quartiles of the serum total and individual -6 PUFA concentrations. After multivariable adjustments, higher serum total -6 PUFA concentration was associated with higher ECP and VO (for ECP, the extreme-quartile difference was 0·77 ml/mmHg (95 % CI 0·38, 1·16, across quartiles < 0·001) and for VO 157 ml/min (95 % CI 85, 230, < 0·001), but not with maximal SBP. Similar associations were observed with serum LA concentration. Higher serum AA concentration was associated with higher ECP but not with VO or maximal SBP. The minor serum -6 PUFA GLA and DGLA were associated with higher maximal SBP during exercise test and DGLA also with higher VO but neither with ECP. In conclusion, especially LA concentration was associated with higher ECP. This may provide one mechanism for the cardioprotective properties of, especially, LA.
-6多不饱和脂肪酸（PUFA）的低摄入量或组织浓度，尤其是主要的-6多不饱和脂肪酸亚油酸（LA），以及低运动心功能（ECP）均与心血管疾病风险相关。然而，-6多不饱和脂肪酸与ECP之间的关联尚不清楚。本研究的目的是探讨血清总-6多不饱和脂肪酸、LA、花生四烯酸（AA）、γ-亚麻酸（GLA）和二高-γ-亚麻酸（DGLA）浓度与ECP及其组成部分之间的横断面关联。总共纳入了1685名来自库奥皮奥缺血性心脏病危险因素研究的42 - 60岁无心血管疾病的男性。采用协方差分析来检查血清总-6多不饱和脂肪酸和个体-6多不饱和脂肪酸浓度四分位数中ECP（最大摄氧量（VO₂）/最大收缩压（SBP））及其组成部分的平均值。经过多变量调整后，较高的血清总-6多不饱和脂肪酸浓度与较高的ECP和VO₂相关（对于ECP，四分位数间极差差异为0·77 ml/mmHg（95%可信区间0·38，1·16，P<0·001），对于VO₂为157 ml/min（95%可信区间85，230，P<0·001），但与最大SBP无关。血清LA浓度也观察到类似的关联。较高的血清AA浓度与较高的ECP相关，但与VO₂或最大SBP无关。少量的血清-6多不饱和脂肪酸GLA和DGLA与运动试验期间较高的最大SBP相关，DGLA也与较高的VO₂相关，但均与ECP无关。总之，尤其是LA浓度与较高的ECP相关。这可能为尤其是LA的心脏保护特性提供一种机制。
