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禁食和固定应激对大鼠多形核吞噬细胞单层吞噬能力的影响。

Effects of fasting and immobilization stresses on the phagocytic capacity of rat polymorphonuclear phagocyte monolayers.

作者信息

Quindos G, Ruiz de Gordoa J C, Burgos A, Ponton J, Cisterna R

出版信息

Arch Immunol Ther Exp (Warsz). 1986;34(5-6):573-6.

PMID:3592941
Abstract

The effect of two different types of acute stress (immobilization and fasting) on the polymorphonuclear leukocyte phagocytic function has been studied in male and female rats. With this aim, a subgroup of rats was under immobilization and fasting, another under complete energy deprivation and a third one (controls), exposed to the normal activity of the animal room, for 15 hours. The stress induction was assessed by controlling weight variations and gastric ulcers generation. Both stressors induced weight loss but only immobilization resulted in the development of gastric ulcer in all the animals studied. Phagocytosis was increased in male rats stressed by fasting and in immobilized female rats. In the remaining subgroups polymorphonuclear leukocyte cells showed a phagocytic capacity within the range of control values. Only comparison of the males group stressed by fasting with the male group stressed by fasting and immobilization showed a significant depression in phagocytosis.

摘要

研究了两种不同类型的急性应激(固定和禁食)对雄性和雌性大鼠多形核白细胞吞噬功能的影响。为此,将一组大鼠进行固定和禁食处理,另一组完全剥夺能量,第三组(对照组)置于动物房正常活动环境中,持续15小时。通过控制体重变化和胃溃疡的产生来评估应激诱导情况。两种应激源均导致体重减轻,但只有固定处理使所有研究动物都出现了胃溃疡。禁食应激的雄性大鼠和固定应激的雌性大鼠的吞噬作用增强。其余亚组的多形核白细胞的吞噬能力在对照值范围内。只有将禁食应激的雄性组与禁食并固定应激的雄性组进行比较时,才显示出吞噬作用有显著降低。

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