Clinical Research Center for Psychiatry, Dalian Seventh Peolpe\'s Hospital, Dalian 116023, China.
Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, the First Affiliated Hospital, Dalian Medical University, Dalian 116021, China.
Curr Alzheimer Res. 2022;19(6):407-419. doi: 10.2174/1567205019666220805114528.
Alzheimer's disease (AD) is the most common form of dementia in the elderly population and places heavy burdens on medical care and nursing. Recently, the psychiatric and behavioral symptoms of prodromal AD, especially mild behavioral impairment (MBI), have attracted much attention. In 2012, Alzheimer's Association International Conference, MBI was proposed as a syndrome with psychiatric and behavioral disturbance before the onset of typical clinical cognitive symptoms in dementia. Increasing lines of evidence have indicated the link between MBI and early AD pathologies including Aβ and tau.
This narrative review aims to summarize the advantages of MBI over other concept of psychiatric and behavioral symptoms associated with AD in the early prediction of AD dementia. We also discuss the possible common genetic basis and pathological mechanisms underlying the interactions between MBI and AD.
Papers cited here were retrieved from PubMed up to February 2022. We selected a total of 95 articles for summary and discussion.
The occurrence of MBI is mainly due to the overlapped genetic and pathological risk factors with AD and is related to the brain's response to environmental stressors. MBI may be a warning sign for the early pathology of AD, and more attention should be paid on the number and duration of MBI symptoms.
MBI may be an early sign and predictor of Alzheimer's disease dementia. Early intervention for MBI may have a positive effect on alleviating long-term cognitive decline.
阿尔茨海默病（AD）是老年人群中最常见的痴呆症形式，给医疗和护理带来了沉重的负担。最近，前驱 AD 的精神和行为症状，尤其是轻度行为障碍（MBI），引起了广泛关注。2012 年，阿尔茨海默病协会国际会议提出，MBI 是痴呆症患者典型临床认知症状出现之前出现的精神和行为障碍综合征。越来越多的证据表明，MBI 与 AD 早期病理之间存在联系，包括 Aβ 和 tau。
本综述旨在总结 MBI 在 AD 早期预测中的优势，相较于 AD 相关的其他精神和行为症状概念。我们还讨论了 MBI 和 AD 之间相互作用的可能共同遗传基础和病理机制。
本文引用的文献均来自 PubMed，检索时间截至 2022 年 2 月。我们共选择了 95 篇文章进行总结和讨论。
MBI 的发生主要归因于与 AD 重叠的遗传和病理风险因素，以及与大脑对环境应激源的反应有关。MBI 可能是 AD 早期病理的一个警告信号，应该更加关注 MBI 症状的数量和持续时间。
MBI 可能是阿尔茨海默病痴呆的早期征象和预测指标。对 MBI 进行早期干预可能对缓解长期认知衰退有积极作用。
