超重和肥胖公务员间歇性禁食的心脏代谢和人体测量结果：一项非随机对照试验的研究方案

Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting Among Civil Servants With Overweight and Obesity: Study Protocol for a Nonrandomized Controlled Trial.

作者信息

Abdullah Shazana Rifham, Azizul Nur Hayati, Wan Mohd Zin Ruziana Mona, Sulaiman Nur Suffia, Mustafa Khalid Norhayati, Mohd Salim Mullahi Jahn Roshan Jahn, Khalil Muhamad Khairul Nazrin, Abu Seman Norhashimah, Zainal Abidin Nur Azlin, Ali Azizan, Tan You Zhuan, Omar Azahadi, Johari Mohammad Zabri, Abdul Aziz Nur Shahida, Baharudin Azli, Seman Zamtira, Ibrahim Wong Norazizah, Md Rasip Mona Lisa, Yusof Hayati Mohd, Md Noh Mohd Fairulnizal

机构信息

Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Shah Alam, Selangor, Malaysia.

Sector for Biostatistic and Data Repository, National Institutes of Health, Ministry of Health, Shah Alam, Selangor, Malaysia.

出版信息

JMIR Res Protoc. 2022 Aug 5;11(8):e33801. doi: 10.2196/33801.

DOI:10.2196/33801

PMID:35930331

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9496805/

Abstract

BACKGROUND

Overweight and obesity among adults are a growing global public health threat and an essential risk factor for various noncommunicable diseases. Although intermittent fasting is a generally new dietary approach to weight management that has been increasingly practiced worldwide, the effectiveness of 2 days per week dry fasting remains unclear.

OBJECTIVE

The Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting study aims to determine the cardiometabolic, anthropometric, dietary intake, and quality of life changes among civil servants with overweight and obesity, following combined intermittent fasting and healthy plate (IFHP) and healthy plate (HP) and explore the participants' experiences.

METHODS

We designed a mixed methods quasi-experimental study to evaluate the effectiveness of the IFHP and HP methods among adults with overweight and obesity. A total of 177 participants were recruited for this study, of which 91 (51.4%) were allocated to the IFHP group and 86 (48.6%) to the HP group. The intervention comprised 2 phases: supervised (12 weeks) and unsupervised (12 weeks). Data collection was conducted at baseline, after the supervised phase (week 12), and after the unsupervised phase (week 24). Serum and whole blood samples were collected from each participant for analysis. Data on sociodemographic factors, quality of life, physical activity, and dietary intake were also obtained using questionnaires during data collection.

RESULTS

Most of the participants were female (147/177, 83.1%) and Malay (141/177, 79.7%). The expected outcomes of this study are changes in body weight, body composition, quality of life, physical activity, dietary intake, and cardiometabolic parameters such as fasting blood glucose, 2-hour postprandial blood glucose, hemoglobin A1c, fasting insulin, and lipid profile.

CONCLUSIONS

The Cardiometabolic and Anthropometric Outcomes of Intermittent Fasting study is a mixed methods study to evaluate the effectiveness of combined IFHP and HP interventions on cardiometabolic and anthropometric parameters and explore participants' experiences throughout the study.

TRIAL REGISTRATION

ClinicalTrials.gov NCT05034653; https://clinicaltrials.gov/ct2/show/NCT05034653.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/33801.

摘要

背景

成年人超重和肥胖是日益严重的全球公共卫生威胁，也是各种非传染性疾病的重要风险因素。尽管间歇性禁食是一种普遍的新型体重管理饮食方法，在全球范围内的应用越来越广泛，但每周进行2天干禁食的有效性仍不明确。

目的

间歇性禁食的心脏代谢和人体测量结果研究旨在确定超重和肥胖公务员在采用间歇性禁食与健康餐盘法（IFHP）以及健康餐盘法（HP）后，其心脏代谢、人体测量、饮食摄入和生活质量的变化，并探索参与者的体验。

方法

我们设计了一项混合方法的准实验研究，以评估IFHP和HP方法对超重和肥胖成年人的有效性。本研究共招募了177名参与者，其中91名（51.4%）被分配到IFHP组，86名（48.6%）被分配到HP组。干预包括两个阶段：监督阶段（12周）和非监督阶段（12周）。在基线、监督阶段结束后（第12周）和非监督阶段结束后（第24周）进行数据收集。从每位参与者采集血清和全血样本进行分析。在数据收集期间，还通过问卷调查获取社会人口学因素、生活质量、身体活动和饮食摄入的数据。