Patel Sunil, McClintock Chad, Booth Christopher, Merchant Shaila, Heneghan Carl, Bankhead Clare
Department of Surgery, Queen's University, Kingston, ON, Canada.
Centre for Evidence Medicine, University of Oxford, Oxford, United Kingdom.
JMIR Res Protoc. 2022 Aug 5;11(8):e38874. doi: 10.2196/38874.
Individuals with rectal cancer require a number of pretreatment investigations, often require multidisciplinary treatment, and require ongoing follow-ups after treatment is completed. Due to the complexity of treatments, large variations in practice patterns and outcomes have been identified. At present, few comprehensive, population-level data sets are available for assessing interventions and outcomes in this group.
Our study aims to create a comprehensive database of individuals with rectal cancer who have been treated in a single-payer, universal health care system. This database will provide an excellent resource that investigators can use to study variations in the delivery of care to and real-world outcomes of this population.
The Ontario Rectal Cancer Cohort database will include comprehensive details about the management and outcomes of individuals with rectal cancer who have been diagnosed in Ontario, Canada (population: 14.6 million), between 2010 and 2019. Linked administrative data sets will be used to construct this comprehensive database. Individual and care provider characteristics, investigations, treatments, follow-ups, and outcomes will be derived and linked. Surgical pathology details, including the stage of disease, histopathology characteristics, and the quality of surgical excision, will be included. Ethics approval for this study was obtained through the Queen's University Health Sciences and Affiliated Teaching Hospitals Research Ethics Board.
Approximately 20,000 individuals who meet the inclusion criteria for this study have been identified. Data analysis is ongoing, with an expected completion date of March 2023. This study was funded through the Canadian Institute of Health Research Operating Grant.
The Ontario Rectal Cancer Cohort will include a comprehensive data set of individuals with rectal cancer who received care within a single-payer, universal health care system. This cohort will be used to determine factors associated with regional variability and adherence to recommended care, and it will allow for an assessment of a number of understudied areas within the delivery of rectal cancer treatment.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/38874.
直肠癌患者需要进行多项预处理检查，通常需要多学科治疗，并且在治疗完成后需要持续随访。由于治疗的复杂性，已发现实践模式和治疗结果存在很大差异。目前，几乎没有全面的、基于人群的数据集可用于评估该群体的干预措施和治疗结果。
我们的研究旨在创建一个在单一支付者的全民医疗保健系统中接受治疗的直肠癌患者综合数据库。该数据库将提供一个优秀的资源，研究人员可用于研究该人群的护理提供差异和实际治疗结果。
安大略直肠癌队列数据库将包括2010年至2019年期间在加拿大安大略省（人口：1460万）被诊断为直肠癌的患者的管理和治疗结果的详细信息。将使用关联的行政数据集来构建这个综合数据库。个人和护理提供者的特征、检查、治疗、随访和治疗结果将被提取并关联起来。手术病理细节，包括疾病分期、组织病理学特征和手术切除质量，也将被纳入。本研究已获得女王大学健康科学与附属教学医院研究伦理委员会的伦理批准。
已确定约20000名符合本研究纳入标准的个体。数据分析正在进行中，预计完成日期为2023年3月。本研究由加拿大卫生研究院运营资助。
安大略直肠癌队列将包括在单一支付者的全民医疗保健系统中接受护理的直肠癌患者的综合数据集。该队列将用于确定与区域差异和遵循推荐护理相关的因素，并将允许评估直肠癌治疗中一些研究不足的领域。
国际注册报告识别码（IRRID）：RR1-10.2196/38874。
