Research Center of Oils and Fats (RCOF), Kermanshah University of Medical Sciences, Kermanshah, Iran.
The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.
Mol Biol Rep. 2022 Nov;49(11):10875-10883. doi: 10.1007/s11033-022-07788-1. Epub 2022 Aug 5.
The process of cell division plays a vital role in cancer progression. Cell proliferation and error-free chromosomes segregation during mitosis are central events in life cycle. Mistakes during cell division generate changes in chromosome content and alter the balances of chromosomes number. Any defects in expression of TIF1 family proteins, SAC proteins network, mitotic checkpoint proteins involved in chromosome mis-segregation and cancer development. Here we discuss the function of organelles deal with the chromosome segregation machinery, proteins and correction mechanisms involved in the accurate chromosome segregation during mitosis.
细胞分裂过程在癌症进展中起着至关重要的作用。有丝分裂过程中细胞的增殖和无差错染色体分离是生命周期中的核心事件。细胞分裂过程中的错误会导致染色体含量的变化，并改变染色体数量的平衡。TIF1 家族蛋白、SAC 蛋白网络、参与染色体错误分离和癌症发展的有丝分裂检查点蛋白的表达缺陷。在这里，我们讨论了细胞器在染色体分离机制中的作用，以及有丝分裂过程中涉及准确染色体分离的蛋白质和校正机制。
