先天性黄疸Gunn大鼠肝脏中特定细胞色素P-450同工酶的增加。
Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.
作者信息
Kapitulnik J, Hardwick J P, Ostrow J D, Webster C C, Park S S, Gelboin H V
出版信息
Biochem J. 1987 Feb 15;242(1):297-300. doi: 10.1042/bj2420297.
Abstract
Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.
摘要
先天性黄疸（jj）的冈恩大鼠肝脏微粒体中细胞色素P-450同工酶P-450c的含量比非黄疸（Jj）大鼠更高。在jj和Jj大鼠之间，未发现P-450b、P-450d和孕烯醇酮-16α-腈诱导的（PCN）P-450含量存在差异。这是首次证明特定细胞色素P-450同工酶的组成性增加与遗传缺陷有关。
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