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先天性黄疸Gunn大鼠肝脏中特定细胞色素P-450同工酶的增加。

Increase in a specific cytochrome P-450 isoenzyme in the liver of congenitally jaundiced Gunn rats.

作者信息

Kapitulnik J, Hardwick J P, Ostrow J D, Webster C C, Park S S, Gelboin H V

出版信息

Biochem J. 1987 Feb 15;242(1):297-300. doi: 10.1042/bj2420297.

DOI:10.1042/bj2420297
PMID:3593244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1147698/
Abstract

Congenitally jaundiced (jj) Gunn rats had a greater hepatic microsomal content of a cytochrome P-450 isoenzyme, P-450c, than did the non-jaundiced (Jj) rats. No differences in content of P-450b, P-450d and pregnenolone-16 alpha-carbonitrile-induced (PCN) P-450 were found between jj and Jj rats. This is the first demonstration of a constitutive increase in a specific cytochrome P-450 isoenzyme in association with a genetic defect.

摘要

先天性黄疸（jj）的冈恩大鼠肝脏微粒体中细胞色素P-450同工酶P-450c的含量比非黄疸（Jj）大鼠更高。在jj和Jj大鼠之间，未发现P-450b、P-450d和孕烯醇酮-16α-腈诱导的（PCN）P-450含量存在差异。这是首次证明特定细胞色素P-450同工酶的组成性增加与遗传缺陷有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dca5/1147698/dec6543e9736/biochemj00261-0288-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dca5/1147698/dec6543e9736/biochemj00261-0288-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dca5/1147698/dec6543e9736/biochemj00261-0288-a.jpg

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本文引用的文献

1
METABOLISM AND DISPOSITION OF C14-BILIRUBIN IN CONGENITAL NONHEMOLYTIC JAUNDICE.先天性非溶血性黄疸中C14 -胆红素的代谢与处置
J Clin Invest. 1963 Nov;42(11):1720-34. doi: 10.1172/JCI104858.
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Congenital jaundice in rats, due to a defect in glucuronide formation.大鼠先天性黄疸，由葡糖醛酸形成缺陷所致。
J Clin Invest. 1958 Aug;37(8):1123-30. doi: 10.1172/JCI103702.
3
Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues.2,3,7,8-四氯二苯并对二恶英诱导的两种细胞色素P-450在肝外组织与肝组织中的差异诱导。
胆碱缺乏饮食对肝炎和肝癌易感大鼠（LEC大鼠）肝脏药物代谢酶变化的增强作用。
Jpn J Cancer Res. 1991 Apr;82(4):390-6. doi: 10.1111/j.1349-7006.1991.tb01861.x.
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Monoclonal antibody-directed radioimmunoassay of specific cytochromes P-450.
J Biol Chem. 1984 Feb 10;259(3):1394-7.
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Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response.
J Biol Chem. 1983 Aug 25;258(16):10182-6.
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UDPglucuronosyltransferase deficiency in man and animals.人和动物中的尿苷二磷酸葡萄糖醛酸基转移酶缺乏症。
Biochem Soc Trans. 1984 Feb;12(1):81-3. doi: 10.1042/bst0120081.
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Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics.结构各异的外源化学物对两种免疫化学相关的大鼠肝脏细胞色素P - 450同工酶，即细胞色素P - 450c和P - 450d的诱导作用。
J Biol Chem. 1983 Apr 10;258(7):4590-8.
8
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450.针对苯巴比妥诱导的大鼠肝脏细胞色素P-450的单克隆抗体。
Biochem Pharmacol. 1984 Jul 1;33(13):2071-81. doi: 10.1016/0006-2952(84)90576-8.
9
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450.抑制3-甲基胆蒽诱导的细胞色素P-450酶活性的单克隆抗体。
Cancer Res. 1982 May;42(5):1798-808.
10
Effects of unconjugated bilirubin on bilirubin-UDP-glucuronyl transferase activity in liver of newborn rats.
Pediatr Res. 1969 May;3(3):205-9. doi: 10.1203/00006450-196905000-00003.