Department of Endodontics, University of Southern Santa Catarina, Palhoça, Santa Catarina, Brazil.
Department of Endodontics, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Aust Endod J. 2023 Aug;49(2):418-427. doi: 10.1111/aej.12670. Epub 2022 Aug 6.
The aim of this integrative review was to identify whether the disinfection procedures performed prior to regenerative endodontic treatment were effective on biofilm removal from the root canals. The research was based on PubMed, Latin American and Caribbean Health Sciences Literature (Lilacs) and Scientific Electronic Library Online (SciELO) databases. Four articles were selected; one of the studies was in vivo and the others ex vivo. Different disinfection procedures were studied, characterised mainly by the use of intracanal medication, highlighting the double antibiotic paste, triple antibiotic paste and calcium hydroxide paste. Disinfection ability was evaluated against Enterococcus faecalis and multispecies biofilms by using the fluorescence technique and colony forming unit counting, for 7 to 21 days. Double antibiotic paste and triple antibiotic paste demonstrated excellent antibiofilm activity, unlike CH paste that showed limited disinfection, even when associated with different antimicrobial agents. Triple antibiotic paste was the most effective medication against biofilm.
本综述的目的是确定再生性牙髓治疗前进行的消毒程序是否能有效去除根管内的生物膜。研究基于 PubMed、拉丁美洲和加勒比健康科学文献 (Lilacs) 和科学电子图书馆在线 (SciELO) 数据库。选择了 4 篇文章；其中一项研究为体内研究，其余为体外研究。研究了不同的消毒程序，主要特点是使用根管内用药，突出了双抗生素糊剂、三抗生素糊剂和氢氧化钙糊剂。通过荧光技术和菌落形成单位计数，在 7 至 21 天内评估了双抗生素糊剂和三抗生素糊剂对粪肠球菌和多物种生物膜的消毒能力。双抗生素糊剂和三抗生素糊剂表现出优异的抗生物膜活性，而 CH 糊剂的消毒效果有限，即使与不同的抗菌剂联合使用也是如此。三抗生素糊剂是对抗生物膜最有效的药物。
