Valverde Marta E, Baca Pilar, Ceballos Laura, Fuentes M Victoria, Ruiz-Linares Matilde, Ferrer-Luque Carmen María
Stomatology Area, Health Sciences Faculty, Rey Juan Carlos University.
Department of Stomatology, School of Dentistry, University of Granada.
Dent Mater J. 2017 May 31;36(3):319-324. doi: 10.4012/dmj.2016-102. Epub 2017 Feb 22.
The antibacterial efficacy of intracanal medicaments for 2 and 7 days, in open apex root canals contaminated with Enterococcus faecalis biofilms was compared. One hundred and thirty-eight standardized uniradicular human roots were inoculated with E. faecalis. Colony forming units (CFU) were recorded before and after medication. Samples were divided in two (2/7 days), and subdivided (n=8/group): triple antibiotic paste (TAP); double antibiotic paste (DAP); dental base paste (DBP), consisting of calcium hydroxide, propylene glycol and calcium carbonate; DBP+0.2% chlorhexidine (CHX); DBP+0.2% cetrimide (CTR); DBP+0.2% CHX+0.2% CTR; 2.5% sodium hypochlorite (NaOCl); and distilled water. At both periods TAP, DAP, DBP+0.2% CHX, DBP+0.2% CTR and DBP+0.2% CHX+0.2% CTR exhibited no growth (NG) of E. faecalis. Distilled water and 2.5% NaOCl obtained the lowest CFU reduction. No growth with DBP was reached only at 7 days. CHX and/or CTR pastes were as effective as DAP and TAP. A 2-day period provided an effective disinfection.
比较了根管内药物在开放根尖根管中对粪肠球菌生物膜污染2天和7天的抗菌效果。138颗标准化的单根人牙根接种了粪肠球菌。记录用药前后的菌落形成单位（CFU）。样本分为两组（2天/7天），再细分（每组n = 8）：三联抗生素糊剂（TAP）；双联抗生素糊剂（DAP）；由氢氧化钙、丙二醇和碳酸钙组成的牙科基底糊剂（DBP）；DBP + 0.2%氯己定（CHX）；DBP + 0.2%西曲溴铵（CTR）；DBP + 0.2% CHX + 0.2% CTR；2.5%次氯酸钠（NaOCl）；以及蒸馏水。在两个时间段，TAP、DAP、DBP + 0.2% CHX、DBP + 0.2% CTR和DBP + 0.2% CHX + 0.2% CTR均未检测到粪肠球菌生长（NG）。蒸馏水和2.5% NaOCl的CFU降低最少。仅在7天时DBP才达到无生长。CHX和/或CTR糊剂与DAP和TAP效果相同。2天的时间可提供有效的消毒。
